Multifunctional photosensitizer-conjugated core-shell Fe3O4@NaYF4:Yb/Er nanocomplexes and their applications in T2-weighted magnetic resonance/upconversion luminescence imaging and photodynamic therapy of cancer cells

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	Multifunctional photosensitizer-conjugated core-shell Fe3O4@NaYF4:Yb/Er nanocomplexes and their applications in T2-weighted magnetic resonance/upconversion luminescence imaging and photodynamic therapy of cancer cells
	曾乐勇、吴爱国 ; Leyong Zeng,a Lingchao Xiang,a Wenzhi Ren,a Jianjun Zheng,c Tianhua Li,a Bin Chen,c Jichao Zhang,b Chengwen Mao,b Aiguo Lib and Aiguo Wua
刊名	RSC Advances
	2013-05-24
期号	3 页码:13915—13925
通讯作者	曾乐勇、吴爱国
合作状况	李雨桐
中文摘要	Due to non-invasive deep imaging and therapy, multifunctional agents of magnetic resonance (MR)/ upconversion luminescence (UCL) imaging and photodynamic therapy (PDT) play an important role in clinical diagnosis and treatment of cancers, and also in the assessment of therapy effect. In this paper, tetra-sulfonic phthalocyanine aluminium (AlPcS4) photosensitizers-conjugated Fe3O4@NaYF4:Yb/Er (NPs- AlPcS4) nanocomplexes were synthesized for the T2-weighted MR/UCL imaging and PDT of cancer cells. The PEG-coated Fe3O4@NaYF4:Yb/Er nanoparticles (NPs) with a core–shell structure showed strong T2- weighted MR relaxivity (r2 = 42.131 mM21 s21) and UCL emission in the visible region (the bands at about 654–674 nm, 545 nm and 524 nm), and were conjugated successfully with AlPcS4 photosensitizer by electrostatic interaction. By direct observation of XFM and staining with Prussian blue, the element distribution and location of NPs in MCF-7 cells were characterized, respectively. Under irradiation from a 980 nm laser, the death ratio of MCF-7 cells incubated with NPs-AlPcS4 nanocomplexes could be up to about 70%. The results indicated that the as-prepared NPs-AlPcS4 nanocomplexes would be a potential candidate as multifunctional nanoprobes for the dual-modal T2-weighted MR/UCL imaging and PDT of cancers in the future.
学科主题	材料科学
原文出处	SCI收录
公开日期	2013-12-16
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/9920]
专题	宁波材料技术与工程研究所_宁波所知识产出
推荐引用方式 GB/T 7714	曾乐勇、吴爱国,Leyong Zeng,a Lingchao Xiang,a Wenzhi Ren,a Jianjun Zheng,c Tianhua Li,a Bin Chen,c Jichao Zhang,b Chengwen Mao,b Aiguo Lib and Aiguo Wua. Multifunctional photosensitizer-conjugated core-shell Fe3O4@NaYF4:Yb/Er nanocomplexes and their applications in T2-weighted magnetic resonance/upconversion luminescence imaging and photodynamic therapy of cancer cells[J]. RSC Advances,2013(3):13915—13925.
APA	曾乐勇、吴爱国,&Leyong Zeng,a Lingchao Xiang,a Wenzhi Ren,a Jianjun Zheng,c Tianhua Li,a Bin Chen,c Jichao Zhang,b Chengwen Mao,b Aiguo Lib and Aiguo Wua.(2013).Multifunctional photosensitizer-conjugated core-shell Fe3O4@NaYF4:Yb/Er nanocomplexes and their applications in T2-weighted magnetic resonance/upconversion luminescence imaging and photodynamic therapy of cancer cells.RSC Advances(3),13915—13925.
MLA	曾乐勇、吴爱国,et al."Multifunctional photosensitizer-conjugated core-shell Fe3O4@NaYF4:Yb/Er nanocomplexes and their applications in T2-weighted magnetic resonance/upconversion luminescence imaging and photodynamic therapy of cancer cells".RSC Advances .3(2013):13915—13925.