Effect of Graphene Oxide on Undifferentiated and Retinoic Acid-Differentiated SH-SY5Y Cells Line

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 宁波所知识产出

	Effect of Graphene Oxide on Undifferentiated and Retinoic Acid-Differentiated SH-SY5Y Cells Line
	张玉杰、Qing Huang ; Min Lv, Yujie Zhang,† Le Liang, Min Wei, Wenbing Hu, Xiaoming Li and Qing Huang*
刊名	Nanoscale
	2012-05-14
卷号	34 期号:4 页码:3861—3866
通讯作者	张玉杰、Qing Huang
合作状况	李雨桐
中文摘要	Graphene oxide (GO), has created an unprecedented opportunity for development and application in biology, due to its abundant functional groups and well water solubility. Recently, the potential toxicity of GO in the environment and in humans has garnered more and more attention. In this paper, we systematically studied the cytotoxicity of GO nanosheets via examining the effect of GO on the morphology, viability and differentiation of human neuroblastoma SH-SY5Y cells line, which was an ideal model used to study neuronal 10 disease in vitro. The results suggested that GO had no obvious cytotoxicity at low concentration (＜80μg/ml) for 96h, but the viability of cells exhibited dose- and time-dependent decrease at high concentration (≥80μg/mL). Moreover, GO did not induce apoptosis. Great interestingly, GO significantly enhanced the differentiation of SH-SY5Y induced-retinoic acid (RA) by evaluating neurite length and the expression of neuronal marker MAP2. These data provide a promising application for neurodegenerative diseases.
学科主题	材料科学
原文出处	其他国内刊物
公开日期	2013-12-16
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/9618]
专题	宁波材料技术与工程研究所_宁波所知识产出
推荐引用方式 GB/T 7714	张玉杰、Qing Huang,Min Lv, Yujie Zhang,† Le Liang, Min Wei, Wenbing Hu, Xiaoming Li and Qing Huang*. Effect of Graphene Oxide on Undifferentiated and Retinoic Acid-Differentiated SH-SY5Y Cells Line[J]. Nanoscale,2012,34(4):3861—3866.
APA	张玉杰、Qing Huang,&Min Lv, Yujie Zhang,† Le Liang, Min Wei, Wenbing Hu, Xiaoming Li and Qing Huang*.(2012).Effect of Graphene Oxide on Undifferentiated and Retinoic Acid-Differentiated SH-SY5Y Cells Line.Nanoscale,34(4),3861—3866.
MLA	张玉杰、Qing Huang,et al."Effect of Graphene Oxide on Undifferentiated and Retinoic Acid-Differentiated SH-SY5Y Cells Line".Nanoscale 34.4(2012):3861—3866.