Enhanced TfR1 Recognition of Myocardial Injury after Acute Myocardial Infarction with Cardiac Fibrosis via Pre-Degrading Excess Fibrotic Collagen | |
Wenwen Yang1,2; Yueqi Wang1; Hongzheng Li2; Feifei Liao2; Yuxuan Peng2; Aimei Lu2; Ling Tan2; Hua Qu2; Linzi Long2; Changgeng Fu2 | |
刊名 | biology
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2024 | |
卷号 | 13期号:4页码:213 |
关键词 | myocardial infarction human serum albumin collagenase I transferrin receptor 1 near-infrared fluorescence imaging |
DOI | 10.3390/biology13040213 |
英文摘要 | The fibrosis process after myocardial infarction (MI) results in a decline in cardiac function due to fibrotic collagen deposition and contrast agents’ metabolic disorders, posing a significant challenge to conventional imaging strategies in making heart damage clear in the fibrosis microenvironment. To address this issue, we developed an imaging strategy. Specifically, we pretreated myocardial fibrotic collagen with collagenase I combined with human serum albumin (HSA-C) and subsequently visualized the site of cardiac injury by near-infrared (NIR) fluorescence imaging using an optical contrast agent (CI, CRT-indocyanine green) targeting transferrin receptor 1 peptides (CRT). The key point of this strategy is that pretreatment with HSA-C can reduce background signal interference in the fibrotic tissue while enhancing CI uptake at the heart lesion site, making the boundary between the injured heart tissue and the normal myocardium clearer. Our results showed that compared to that in the untargeted group, the normalized fluorescence intensity of cardiac damage detected by NIR in the targeted group increased 1.28-fold. The normalized fluorescence intensity increased 1.21-fold in the pretreatment group of the targeted groups. These data demonstrate the feasibility of applying pretreated fibrotic collagen and NIR contrast agents targeting TfR1 to identify ferroptosis at sites of cardiac injury, and its clinical value in the management of patients with MI needs further study. |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/57131] ![]() |
专题 | 自动化研究所_中国科学院分子影像重点实验室 |
作者单位 | 1.CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences 2.Graduate School, China Academy of Chinese Medical Sciences |
推荐引用方式 GB/T 7714 | Wenwen Yang,Yueqi Wang,Hongzheng Li,et al. Enhanced TfR1 Recognition of Myocardial Injury after Acute Myocardial Infarction with Cardiac Fibrosis via Pre-Degrading Excess Fibrotic Collagen[J]. biology,2024,13(4):213. |
APA | Wenwen Yang.,Yueqi Wang.,Hongzheng Li.,Feifei Liao.,Yuxuan Peng.,...&Changgeng Fu.(2024).Enhanced TfR1 Recognition of Myocardial Injury after Acute Myocardial Infarction with Cardiac Fibrosis via Pre-Degrading Excess Fibrotic Collagen.biology,13(4),213. |
MLA | Wenwen Yang,et al."Enhanced TfR1 Recognition of Myocardial Injury after Acute Myocardial Infarction with Cardiac Fibrosis via Pre-Degrading Excess Fibrotic Collagen".biology 13.4(2024):213. |
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