Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe<sub>3</sub>O<sub>4</sub> Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy

doi:10.2147/IJN.S428687

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe₃O₄ Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy
	Jin, Yushen 2; Cheng, Zhongquan 4; Yuan, Zhu 4; Du, Yang 3; Tian, Jie 3; Shao, Bing 1,2
刊名	INTERNATIONAL JOURNAL OF NANOMEDICINE
	2024
卷号	19 页码:189-208
关键词	porous hollow structure magnetic particle imaging fluorescence imaging synergistic treatment theranostics
ISSN号	1178-2013
DOI	10.2147/IJN.S428687
通讯作者	Shao, Bing(shaobingch@sina.com)
英文摘要	Purpose: Liver cancer is considered as the third leading cause of cancer-related deaths, with hepatocellular carcinoma (HCC) accounting for approximately 90% of liver cancers. Improving the treatment of HCC is a serious challenge today. The primary objective of this study was to construct SP94-Fe3O4@ICG&DOX nanoparticles and investigate their potential diagnosis and treatment effect benefits on HCC.Methods: Firstly, we synthesized and characterized SP94-Fe3O4@ICG&DOX nanoparticles and confirmed their in vitro release behavior, photothermal and photodynamic performance. Moreover, the in vivo imaging capability was also observed. Finally, the inhibitory effects on Hepa1-6 in vitro and in vivo were observed as well as biosafety.Results: SP94-Fe3O4@ICG&DOX nanoparticles have a size of similar to 22.1 nm, with an encapsulation efficiency of 45.2% for ICG and 42.7% for DOX, showing excellent in vivo MPI and fluorescence imaging capabilities for precise tumor localization, and synergistic photo-chemotherapy (pH-and thermal-sensitive drug release) against tumors under irradiation. With the assistance of a fluorescence molecular imaging system or MPI scanner, the location and contours of the tumor were clearly visible. Under a constant laser irradiation (808 nm, 0.6 W/cm2) and a set concentration (50 mu g/mL), the temperature of the solution could rapidly increase to similar to 45 C-degrees, which could effectively kill the tumor cells. It could be effectively uptaken by HCC cells and significantly inhibit their proliferation under the laser irradiation (100% inhibition rate for HCC tumors). And most importantly, our nanoparticles exhibited favorable biocompatibility with normal tissues and cells.Conclusion: This versatile agent can serve as an intelligent and promising nanoplatform that integrates multiple accurate diagnoses, precise positioning of cancer tissue, and effective coordination with synergistic tumor photodynamic therapy.
资助项目	National Natural Science Foundation of China[82072098]
WOS关键词	CANCER ; PERFORMANCE ; DOXORUBICIN ; GRP78
WOS研究方向	Science & Technology - Other Topics ; Pharmacology & Pharmacy
语种	英语
出版者	DOVE MEDICAL PRESS LTD
WOS记录号	WOS:001145402800001
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/55464]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Shao, Bing
作者单位	1.China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China 2.Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China 3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Jin, Yushen,Cheng, Zhongquan,Yuan, Zhu,et al. Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe₃O₄ Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2024,19:189-208.
APA	Jin, Yushen,Cheng, Zhongquan,Yuan, Zhu,Du, Yang,Tian, Jie,&Shao, Bing.(2024).Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe₃O₄ Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy.INTERNATIONAL JOURNAL OF NANOMEDICINE,19,189-208.
MLA	Jin, Yushen,et al."Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe₃O₄ Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy".INTERNATIONAL JOURNAL OF NANOMEDICINE 19(2024):189-208.