Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway

	Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway
	Liu Qi 1; Li Wenjun 1; Lu Lina 2; Liu Bin 2; Du Zhenning 3; Qin Song 1
刊名	Journal of Oceanology and Limnology
	2019
卷号	37 期号:5 页码:1678-1685
关键词	phycocyanin inflammatory TLR2-MyD88-NF-κB signaling pathway
ISSN号	2096-5508
其他题名	Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway
英文摘要	Phycocyanin (PC),a natural algal protein,is reported for having anti-oxidant and antiinflammatory properties.We investigated its ability to attenuate lung inflammation in mice subjected to X-ray radiation.Male C57BL/6 mice were assigned to the control,total body irradiation,PC pretreatment,and PC treatment groups.Mice in the PC pretreatment group were gavaged with 200 mg/kg PC for 7 consecutive days before irradiation,and those in the PC treatment group were gavaged with 200 mg/kg PC for 7 consecutive days after irradiation.Lungs were collected on Day 7 after irradiation exposure.Hematoxylin and eosin staining of mouse lung sections showed considerable inflammation damage 7 days after irradiation compared with the control lung but a reduction in pathological injury in the PC treatment group.Pretreatment or treatment with PC significantly decreased levels of interleukin-6 and tumor necrosis factor-α in the lung,and also increased the relative mRNA expression of superoxide dismutase and glutathione.In vivo,PC significantly reduced the expression of Toll-like receptor TLR2,myeloid differentiation primary response Myd88,and nuclear factor NF-κB,at both the transcriptional and translation level.Taken together,these data indicated that PC attenuated lung inflammatory damage induced by radiation by blocking the TLR2- MyD88-NF-κB signaling pathway.Therefore,PC could be a protective agent against radiation-induced inflammatory damage in normal tissues.
语种	英语
CSCD记录号	CSCD:6556057
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/35033]
专题	中国科学院烟台海岸带研究所
作者单位	1.中国科学院烟台海岸带研究所 2.School of Nuclear Science and Technology,Lanzhou University 3.School of Pharmacy,Yantai University
推荐引用方式 GB/T 7714	Liu Qi,Li Wenjun,Lu Lina,et al. Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway[J]. Journal of Oceanology and Limnology,2019,37(5):1678-1685.
APA	Liu Qi,Li Wenjun,Lu Lina,Liu Bin,Du Zhenning,&Qin Song.(2019).Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway.Journal of Oceanology and Limnology,37(5),1678-1685.
MLA	Liu Qi,et al."Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway".Journal of Oceanology and Limnology 37.5(2019):1678-1685.