Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus | |
Ding, Kui1,2,3; Xu, Qinzeng1,3; Zhang, Xuelei1,3; Liu, Shilin2 | |
刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY |
2023-11-01 | |
卷号 | 266页码:11 |
关键词 | Apostichopus japonicus BDE-47 Nervous system UPLC-Triple-TOF-MS Metabolite Neurotoxicity |
ISSN号 | 0147-6513 |
DOI | 10.1016/j.ecoenv.2023.115558 |
通讯作者 | Ding, Kui(dingkui@fio.org.cn) |
英文摘要 | The persistent organic pollutant 2,2 ',4,4 '-Tetrabromodiphenyl ether (BDE-47), a prevalent congener among polybrominated diphenyl ethers (PBDEs), exhibits potent bioaccumulation and toxicity. Despite extensive research into the adverse effects of BDE-47, its neurotoxicity in sea cucumbers remains unexplored. Given the crucial role of the sea cucumber's nervous system in survival and adaptation, evaluating the impacts of BDE-47 is vital for sustainable aquaculture and consumption. In this study, we employed ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Triple-TOF-MS) to analyze metabolomic changes in neuro-related tissues of Apostichopus japonicus exposed to low (0.1 mu g/L), medium (1.0 mu g/L), and high (10.0 mu g/L) BDE-47 concentrations. We identified significantly changed metabolites in each exposure group (87 in low, 79 in medium, and 102 in high), affecting a variety of physiological processes such as steroid hormone balance, nucleotide metabolism, energy metabolism, neurotransmitter levels, and neuroprotection. In addition, we identified concentration-dependent, common, and some other metabolic responses in the neuro-related tissues. Our findings reveal critical insights into the neurotoxic effects of BDE-47 in sea cucumbers and contribute to risk assessment related to BDE-47 exposure in the sea cucumber industry, paving the way for future neurotoxicological research in invertebrates. |
资助项目 | National Natural Science Founda-tion of China[42106131] |
WOS关键词 | POLYBROMINATED DIPHENYL ETHERS ; BROMINATED FLAME RETARDANTS ; OXIDATIVE STRESS ; CALCIUM HOMEOSTASIS ; NEONATAL EXPOSURE ; ACID-METABOLISM ; SERINE RACEMASE ; IMMUNE FUNCTION ; VITAMIN-A ; BEHAVIOR |
WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
语种 | 英语 |
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
WOS记录号 | WOS:001095010000001 |
内容类型 | 期刊论文 |
源URL | [http://ir.qdio.ac.cn/handle/337002/183843] |
专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
通讯作者 | Ding, Kui |
作者单位 | 1.Minist Nat Resources, Inst Oceanog 1, Key Lab Marine Ecoenvironm Sci & Technol, Qingdao 266061, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266061, Peoples R China |
推荐引用方式 GB/T 7714 | Ding, Kui,Xu, Qinzeng,Zhang, Xuelei,et al. Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2023,266:11. |
APA | Ding, Kui,Xu, Qinzeng,Zhang, Xuelei,&Liu, Shilin.(2023).Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,266,11. |
MLA | Ding, Kui,et al."Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 266(2023):11. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论