Redox-sensitive self-assembled micelles based on low molecular weight chitosan-lipoic acid conjugates for the delivery of doxorubicin: Effect of substitution degree of lipoic acid

doi:10.1016/j.ijbiomac.2023.125849

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Redox-sensitive self-assembled micelles based on low molecular weight chitosan-lipoic acid conjugates for the delivery of doxorubicin: Effect of substitution degree of lipoic acid
	Yuan, Yuting 1,2,5; Wang, Zhenhua 4; Su, Shengjia 3; Mi, Yingqi 1,2; Li, Qing 1,2; Dong, Fang 1,2; Tan, Wenqiang 1,2; Guo, Zhanyong 1,2,5
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2023-08-30
卷号	247 页码:14
关键词	Amphiphilic polymer Doxorubicin Drug delivery Release-trigger release Self-assembled micelle
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2023.125849
通讯作者	Tan, Wenqiang(wqtan@yic.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	Amphiphilic low molecular weight chitosan-lipoic acid (LC-LA) conjugates with different degrees of substitution (DS) of LA were synthesized by N, N & PRIME;-carbonyldiimidazole (CDI) catalysis to self-assemble into redox-sensitive micelles. Critical micelle concentration (CMC), size, zeta potential, biocompatibility and redox-sensitive behavior of blank micelles were investigated. The results indicated that blank micelles with low CMC, nano-scale size and positive zeta potential showed excellent biocompatibility and redox-sensitive behavior. Doxoru-bicin (Dox) loaded micelles were prepared by encapsulating Dox into blank micelles. The loading ability, trigger-release behavior, antitumor activity and cellular uptake of Dox loaded micelles were studied. The results demonstrated that Dox loaded micelles with superior loading ability exhibited redox-trigger behavior, strong antitumor activity and increased cellular uptake efficiency against A549 cell. Besides, the effect of DS of LA on above properties was estimated. An increase in DS of LA reduced the CMC and cumulative release amount of Dox, but improved the loading efficiency, antitumor activity, and cellular uptake of Dox loaded micelles, which resulted from stronger interaction of hydrophobic groups in micelles with the DS of LA increased. Overall, self-assembled LC-LA micelles with good biosecurity and redox-sensitive behavior hold promising application prospects in Dox delivery and improving cancer therapeutic effect of Dox.
WOS关键词	POLYMERIC MICELLES ; DRUG-DELIVERY ; DOCETAXEL ; RELEASE
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
WOS记录号	WOS:001048764100001
资助机构	Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province of China ; Shandong Key Ramp;D plan, Major Scientific and Tech-nological Innovation Project ; Science amp; Technology Specific Projects in Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/33441]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Tan, Wenqiang; Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 3.Shandong Saline Alkali Land Modern Agr Co, Dongying 257300, Peoples R China 4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Yuting,Wang, Zhenhua,Su, Shengjia,et al. Redox-sensitive self-assembled micelles based on low molecular weight chitosan-lipoic acid conjugates for the delivery of doxorubicin: Effect of substitution degree of lipoic acid[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,247:14.
APA	Yuan, Yuting.,Wang, Zhenhua.,Su, Shengjia.,Mi, Yingqi.,Li, Qing.,...&Guo, Zhanyong.(2023).Redox-sensitive self-assembled micelles based on low molecular weight chitosan-lipoic acid conjugates for the delivery of doxorubicin: Effect of substitution degree of lipoic acid.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,247,14.
MLA	Yuan, Yuting,et al."Redox-sensitive self-assembled micelles based on low molecular weight chitosan-lipoic acid conjugates for the delivery of doxorubicin: Effect of substitution degree of lipoic acid".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 247(2023):14.