Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups

doi:10.3390/md21120606

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups
	Wang, Linqing 1,4,5; Guo, Rui 1,4,5; Liang, Xiaorui 3; Ji, Yuting 1,4,5; Zhang, Jingjing 1,5; Gai, Guowei 2; Guo, Zhanyong 1,4,5
刊名	MARINE DRUGS
	2023-12-01
卷号	21 期号:12 页码:21
关键词	antioxidant activity carboxymethyl chitosan derivatives quinoline
DOI	10.3390/md21120606
通讯作者	Zhang, Jingjing(jingjingzhang@yic.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	A total of 16 novel carboxymethyl chitosan derivatives bearing quinoline groups in four classes were prepared by different synthetic methods. Their chemical structures were confirmed by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and elemental analysis. The antioxidant experiment results in vitro (including DPPH radical scavenging ability, superoxide anion radical scavenging ability, hydroxyl radical scavenging ability, and ferric reducing antioxidant power) demonstrated that adding quinoline groups to chitosan (CS) and carboxymethyl chitosan (CMCS) enhanced the radical scavenging ability of CS and CMCS. Among them, both N, O-CMCS derivatives and N-TM-O-CMCS derivatives showed DPPH radical scavenging over 70%. In addition, their scavenging of superoxide anion radicals reached more than 90% at the maximum tested concentration of 1.6 mg/mL. Moreover, the cytotoxicity assay was carried out on L929 cells by the MTT method, and the results indicated that all derivatives showed no cytotoxicity (cell viability > 75%) except O-CMCS derivative 1a, which showed low cytotoxicity at 1000 mu g/mL (cell viability 50.77 +/- 4.67%). In conclusion, the carboxymethyl chitosan derivatives bearing quinoline groups showed remarkable antioxidant ability and weak cytotoxicity, highlighting their potential use in food and medical applications.
WOS关键词	COMPOSITE
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:001132743900001
资助机构	Natural Science Foundation of Shandong Province of China ; Institutional Center for the shared technologies and facilities of the Yantai Institute of Coastal Zone Research
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/33132]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Zhang, Jingjing; Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Shandong Saline Alkali Land Modern Agr Co, Dongying 257300, Peoples R China 3.Naval Aviat Univ, Sch Basic Sci Aviat, Yantai 264001, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Wang, Linqing,Guo, Rui,Liang, Xiaorui,et al. Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups[J]. MARINE DRUGS,2023,21(12):21.
APA	Wang, Linqing.,Guo, Rui.,Liang, Xiaorui.,Ji, Yuting.,Zhang, Jingjing.,...&Guo, Zhanyong.(2023).Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups.MARINE DRUGS,21(12),21.
MLA	Wang, Linqing,et al."Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups".MARINE DRUGS 21.12(2023):21.