pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release

doi:10.1016/j.ijbiomac.2023.128590

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release
	Ma, Bing 1,2,3; Li, Qing 1,3; Mi, Yingqi 1,3; Zhang, Jingjing 1,3; Tan, Wenqiang 1,3; Guo, Zhanyong 1,2,3
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2024-02-01
卷号	257 页码:16
关键词	Benzimidazole-chitosan quaternary ammonium salt Nanogels pH-responsive Antioxidant activity Antitumor activity
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2023.128590
通讯作者	Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	pH-responsive nanogels have played an increasingly momentous role in tumor treatment. The focus of this study is to design and develop pH-responsive benzimidazole-chitosan quaternary ammonium salt (BIMIXHAC) nanogels for the controlled release of doxorubicin hydrochloride (DOX) while enhancing its hydrophilicity. BIMIXHAC is crosslinked with carboxymethyl chitosan (CMC), hyaluronic acid sodium salt (HA), and sodium alginates (SA) using an ion crosslinking method. The chemical structure of chitosan derivatives was verified by 1H NMR and FT-IR techniques. Compared to hydroxypropyl trimethyl ammonium chloride chitosan (HACC)-based nanogels, BIMIXHAC-based nanogels exhibit better drug encapsulation efficiency and loading capacity (BIMIXHAC-D-HA 91.76 %, and 32.23 %), with pH-responsive release profiles and accelerated release in vitro. The series of nanogels formed by crosslinking with three different polyanionic crosslinkers have different particle size potentials and antioxidant properties. BIMIXHAC-HA, BIMIXHAC-SA and BIMIXHAC-CMC demonstrate favorable antioxidant capability. In addition, cytotoxicity tests showed that BIMIXHAC-based nanogels have high biocompatibility. BIMIXHAC-based nanogels exhibit preferable anticancer effects on MCF-7 and A549 cells. Furthermore, the BIMIXHAC-D-HA nanogel was 2.62 times less toxic than DOX to L929 cells. These results suggest that BIMIXHAC-based nanogels can serve as pH-responsive nanoplatforms for the delivery of anticancer drugs.
WOS关键词	HYALURONIC-ACID ; DOXORUBICIN ; ALGINATE ; CHITOSAN ; BIOCOMPATIBILITY ; CARDIOTOXICITY ; NANOPARTICLES ; RETENTION
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
WOS记录号	WOS:001134245300001
资助机构	The 2023 annual Special Research Assistant Project of Chinese Academy of Sciences ; Shandong Key R D Plan ; Major Scientific and Technological Innovation Project ; Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province of China
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/33126]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Ma, Bing,Li, Qing,Mi, Yingqi,et al. pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,257:16.
APA	Ma, Bing,Li, Qing,Mi, Yingqi,Zhang, Jingjing,Tan, Wenqiang,&Guo, Zhanyong.(2024).pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,257,16.
MLA	Ma, Bing,et al."pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 257(2024):16.