Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians

doi:10.1016/j.scitotenv.2023.168941

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中国科学院牟平海岸带环境综合试验站

	Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians
	Zhang, Tianyu 1,2,3; Wang, Xin 1,2,3; Zhang, Qianqian 1,2; Yang, Dinglong 1,2; Zhang, Xiaoli 1,2; Liu, Hui 1,2; Dong, Zhijun 1,2; Zhao, Jianmin 1,2,4
刊名	SCIENCE OF THE TOTAL ENVIRONMENT
	2024-02-20
卷号	912 页码:14
关键词	Antibiotics residues Ocean acidification Physiological response Metabolomics Bay scallop
ISSN号	0048-9697
DOI	10.1016/j.scitotenv.2023.168941
通讯作者	Zhao, Jianmin(jmzhao@yic.ac.cn)
英文摘要	Coastal areas are confronted with compounding threats arising from both climatic and non-climatic stressors. Antibiotic pollution and ocean acidification are two prevalently concurrent environmental stressors. Yet their interactive effects on marine biota have not been investigated adequately and the compound hazard remain obscure. In this study, bay scallops Argopecten irradians irradians were exposed to multiple antibiotics (sulfamethoxazole, tetracycline, oxytetracycline, norfloxacin, and erythromycin, each at a concentration of 1 mu g/L) combined with/without acidic seawater (pH 7.6) for 35 days. The single and interactive effects of the two stressors on A. irradians irradians were determined from multidimensional bio-responses, including energetic physiological traits as well as the molecular underpinning (metabolome and expressions of key genes). Results showed that multiple antibiotics predominantly enhanced the process of DNA repair and replication via disturbing the purine metabolism pathway. This alternation is perhaps to cope with the DNA damage induced by oxidative stress. Ocean acidification mainly disrupted energy metabolism and ammonia metabolism of the scallops, as evidenced by the increased ammonia excretion rate, the decreased O:N ratio, and perturbations in amino acid metabolism pathways. Moreover, the antagonistic effects of multiple antibiotics and ocean acidification caused alternations in the relative abundance of neurotransmitter and gene expression of neurotransmitter receptors, which may lead to neurological disorders in scallops. Overall, the revealed alternations in physiological traits, metabolites and gene expressions provide insightful information for the health status of bivalves in a natural environmental condition under the climate change scenarios.
WOS关键词	OXIDATIVE STRESS ; SEASONAL-VARIATION ; RESISTANCE GENES ; COASTAL WATER ; DNA ; MUSSELS ; RESPONSES ; TOXICITY ; ACID ; SEA
WOS研究方向	Environmental Sciences & Ecology
语种	英语
WOS记录号	WOS:001133719600001
资助机构	Strategic Priority Research Program of the Chinese Academy of Sciences ; National Science & Technology Fundamental Resources Investigation Program of China ; Seed Project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/34362]
专题	中国科学院牟平海岸带环境综合试验站
通讯作者	Zhao, Jianmin
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resources Utilizat, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264117, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc & Ecol Remediat, Yantai 264117, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Tianyu,Wang, Xin,Zhang, Qianqian,et al. Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2024,912:14.
APA	Zhang, Tianyu.,Wang, Xin.,Zhang, Qianqian.,Yang, Dinglong.,Zhang, Xiaoli.,...&Zhao, Jianmin.(2024).Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians.SCIENCE OF THE TOTAL ENVIRONMENT,912,14.
MLA	Zhang, Tianyu,et al."Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians".SCIENCE OF THE TOTAL ENVIRONMENT 912(2024):14.