Intrinsic and extrinsic pathways of apoptosis induced by multiple antibiotics residues and ocean acidification in hemocytes of scallop Argopecten irradians irradians: An interactionist perspective

doi:10.1016/j.ecoenv.2023.115806

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中国科学院牟平海岸带环境综合试验站

	Intrinsic and extrinsic pathways of apoptosis induced by multiple antibiotics residues and ocean acidification in hemocytes of scallop Argopecten irradians irradians: An interactionist perspective
	Zhang, Tianyu 1,2,4; Wang, Xin 1,2,4; Zhang, Qianqian 1,4; Li, Ke 1; Yang, Dinglong 1,4; Zhang, Xiaoli 1,4; Liu, Hui 1,4; Wang, Qing 1,4; Dong, Zhijun 1,4; Yuan, Xiutang 1,4
刊名	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
	2024
卷号	269 页码:12
关键词	Antibiotics residues Ocean acidification Apoptosis Bay scallop
ISSN号	0147-6513
DOI	10.1016/j.ecoenv.2023.115806
通讯作者	Zhao, Jianmin(jmzhao@yic.ac.cn)
英文摘要	The increasing prevalence of antibiotics in seawater across global coastal areas, coupled with the ocean acidification induced by climate change, present a multifaceted challenge to marine ecosystems, particularly impacting the key physiological processes of marine organisms. Apoptosis is a critical adaptive response essential for maintaining cellular homeostasis and defending against environmental threats. In this study, bay scallops Argopecten irradians irradians were exposed to multiple antibiotics (sulfamethoxazole, tetracycline, oxytetracycline, norfloxacin, and erythromycin, each at a concentration of 1 mu g/L) combined with/without acidic seawater (pH 7.6) for 35 days. The single and interactive effects of the two stressors on apoptosis and the underlying mechanisms in hemocytes of A. irradians irradians were determined through flow cytometry analysis, comet assay, oxidative stress biomarkers analysis, and transcriptome analysis. Results showed that apoptosis could be triggered by either AM exposure or OA exposure, but through different pathways. Exposure to AM leads to mitochondrial dysfunction and oxidative damage, which in turn triggers apoptosis via a series of cellular events in both intrinsic and extrinsic pathways. Conversely, while OA exposure similarly induced apoptosis, its effects are comparatively subdued and are predominantly mediated through the intrinsic pathway. Additionally, the synergistic effects of AM and OA exposure induced pronounced mitochondrial dysfunction and oxidative damages in the hemocytes of A. irradians irradians. Despite the evident cellular distress and the potential initiation of apoptotic pathways, the actual execution of apoptosis appears to be restrained, which might be attributed to an energy deficit within the hemocytes. Our findings underscore the constrained tolerance capacity of A. irradians irradians when faced with multiple environmental stressors, and shed light on the ecotoxicity of antibiotic pollution in the ocean under prospective climate change scenarios.
WOS关键词	SEAWATER ACIDIFICATION ; OXIDATIVE STRESS ; PACIFIC OYSTER ; DNA-DAMAGE ; CELL-DEATH ; MITOCHONDRIA ; DICLOFENAC ; PHARMACEUTICALS ; BIOACCUMULATION ; RECOGNITION
WOS研究方向	Environmental Sciences & Ecology ; Toxicology
语种	英语
WOS记录号	WOS:001141450100001
资助机构	Strategic Priority Research Program of the Chinese Academy of Sciences ; National Science & Technology Fundamental Resources Investigation Program of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/34332]
专题	中国科学院牟平海岸带环境综合试验站
通讯作者	Zhao, Jianmin
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resources Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc & Ecol Remediat, Yantai 264117, Peoples R China 4.Chinese Acad Sci, Muping Coastal Environm Res Stn, Yantai Inst Coastal Zone Res, Yantai 264117, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Tianyu,Wang, Xin,Zhang, Qianqian,et al. Intrinsic and extrinsic pathways of apoptosis induced by multiple antibiotics residues and ocean acidification in hemocytes of scallop Argopecten irradians irradians: An interactionist perspective[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2024,269:12.
APA	Zhang, Tianyu.,Wang, Xin.,Zhang, Qianqian.,Li, Ke.,Yang, Dinglong.,...&Zhao, Jianmin.(2024).Intrinsic and extrinsic pathways of apoptosis induced by multiple antibiotics residues and ocean acidification in hemocytes of scallop Argopecten irradians irradians: An interactionist perspective.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,269,12.
MLA	Zhang, Tianyu,et al."Intrinsic and extrinsic pathways of apoptosis induced by multiple antibiotics residues and ocean acidification in hemocytes of scallop Argopecten irradians irradians: An interactionist perspective".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 269(2024):12.