Disrupted Gray Matter Networks Associated with Cognitive Dysfunction in Cerebral Small Vessel Disease

doi:10.3390/brainsci13101359

	Disrupted Gray Matter Networks Associated with Cognitive Dysfunction in Cerebral Small Vessel Disease
	Gao, Yian 7; Wang, Shengpei 5,6; Xin, Haotian 4; Feng, Mengmeng 4; Zhang, Qihao 3; Sui, Chaofan 7; Guo, Lingfei 7; Liang, Changhu 2; Wen, Hongwei 1
刊名	BRAIN SCIENCES
	2023-10-01
卷号	13 期号:10 页码:19
关键词	cerebral small vessel disease cerebral microbleeds voxel-based morphometry gray matter networks graph theory
DOI	10.3390/brainsci13101359
通讯作者	Guo, Lingfei(wenhongwei@swu.edu.cn) ; Liang, Changhu(tigerlch@163.com) ; Wen, Hongwei(glfsci@163.com)
英文摘要	This study aims to investigate the disrupted topological organization of gray matter (GM) structural networks in cerebral small vessel disease (CSVD) patients with cerebral microbleeds (CMBs). Subject-wise structural networks were constructed from GM volumetric features of 49 CSVD patients with CMBs (CSVD-c), 121 CSVD patients without CMBs (CSVD-n), and 74 healthy controls. The study used graph theory to analyze the global and regional properties of the network and their correlation with cognitive performance. We found that both the control and CSVD groups exhibited efficient small-world organization in GM networks. However, compared to controls, CSVD-c and CSVD-n patients exhibited increased global and local efficiency (Eglob/Eloc) and decreased shortest path lengths (Lp), indicating increased global integration and local specialization in structural networks. Although there was no significant global topology change, partially reorganized hub distributions were found between CSVD-c and CSVD-n patients. Importantly, regional topology in nonhub regions was significantly altered between CSVD-c and CSVD-n patients, including the bilateral anterior cingulate gyrus, left superior parietal gyrus, dorsolateral superior frontal gyrus, and right MTG, which are involved in the default mode network (DMN) and sensorimotor functional modules. Intriguingly, the global metrics (Eglob, Eloc, and Lp) were significantly correlated with MoCA, AVLT, and SCWT scores in the control group but not in the CSVD-c and CSVD-n groups. In contrast, the global metrics were significantly correlated with the SDMT score in the CSVD-s and CSVD-n groups but not in the control group. Patients with CSVD show a disrupted balance between local specialization and global integration in their GM structural networks. The altered regional topology between CSVD-c and CSVD-n patients may be due to different etiological contributions, which may offer a novel understanding of the neurobiological processes involved in CSVD with CMBs.
资助项目	The authors thank all of the volunteers and patients for their participation in our study.
WOS关键词	VOXEL-BASED MORPHOMETRY ; SUPERIOR PARIETAL LOBULE ; MIDDLE TEMPORAL GYRUS ; CO-SPEECH GESTURES ; FUNCTIONAL CONNECTIVITY ; STRUCTURAL NETWORKS ; CORTICAL THICKNESS ; BRAIN ; ORGANIZATION ; ATROPHY
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	MDPI
WOS记录号	WOS:001092498100001
资助机构	The authors thank all of the volunteers and patients for their participation in our study.
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/54280]
专题	智能机器人系统研究
通讯作者	Guo, Lingfei; Liang, Changhu; Wen, Hongwei
作者单位	1.Southwest Univ, Fac Psychol, Key Lab Cognit & Personal, Minist Educ, Chongqing 400715, Peoples R China 2.Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Radiol, Jing Wu Rd 324, Jinan 250021, Peoples R China 3.Weill Cornell Med Coll, Dept Radiol, 407 East 61st St, New York, NY 10044 USA 4.Capital Med Univ, Xuanwu Hosp, Dept Radiol & Nucl Med, 45 Changchun St, Beijing 100054, Peoples R China 5.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 6.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing 100040, Peoples R China 7.Shandong First Med Univ, Dept Radiol, Key Lab Endocrine Glucose & Lipids Metab & Brain A, Minist Educ,Shandong Prov Hosp, Jinan 250021, Peoples R China
推荐引用方式 GB/T 7714	Gao, Yian,Wang, Shengpei,Xin, Haotian,et al. Disrupted Gray Matter Networks Associated with Cognitive Dysfunction in Cerebral Small Vessel Disease[J]. BRAIN SCIENCES,2023,13(10):19.
APA	Gao, Yian.,Wang, Shengpei.,Xin, Haotian.,Feng, Mengmeng.,Zhang, Qihao.,...&Wen, Hongwei.(2023).Disrupted Gray Matter Networks Associated with Cognitive Dysfunction in Cerebral Small Vessel Disease.BRAIN SCIENCES,13(10),19.
MLA	Gao, Yian,et al."Disrupted Gray Matter Networks Associated with Cognitive Dysfunction in Cerebral Small Vessel Disease".BRAIN SCIENCES 13.10(2023):19.