| Stretchable Electronic Facial Masks for Skin Electroporation | |
| Xu, Xinkai11,12; Guo, Liang10,12; Liu, Hao10,12; Zhou, Zanxin11,12; Li, Shuang11,12; Gu, Qi7,8,9; Ding, Shenglong6,9; Guo, Haitao9; Yan, Yan5; Lan, Yuqun11,12 | |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 2023-11-21 | |
| 页码 | 14 |
| 关键词 | conductive ink conductive silicone skin electroporation stretchable electronics |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.202311144 |
| 通讯作者 | Su, Yewang(yewangsu@imech.ac.cn) |
| 英文摘要 | A stretchable electronic facial mask (SEFM) for skin electroporation by transdermal drug delivery is introduced. The SEFM exhibits characteristics of reusability, water-resistant, low cost, and portability. To achieve these objectives while maintaining satisfactory mechanical and electrical performance of the device, two main areas are innovated: (1) Grinding and doping modification of conductive ink to enhance its adhesion to silicone and increase conductivity through material research, as well as mechanical structure design for stretching stability of conductive ink electrodes. (2) Doping modification of high-temperature vulcanizes silicone to address the issue of increased resistance during encapsulation due to the swell of conductive ink. The SEFM designed with these innovations, is validated in rat experiments, demonstrating a 3-4 times increase in drug intake compared to the control group without skin electroporation. Safety is confirmed, and the promotion of niacinamide drug delivery is verified in human volunteers. The materials-modified conductive ink and conductive silicone proposed in SEFM can be employed in other flexible wearable devices, and this platform has the potential for future integration of additional components to achieve expanded functionality and productization. A stretchable electronic facial mask (SEFM) for skin electroporation by transdermal drug delivery, enabling the delivery of drugs such as sodium hyaluronate (SH), aloe powder, beta-glucose, and d-panthenol. The SEFM significantly enhances drug intake, with a 3-4 times increase. This platform holds the potential for future integration of additional components to expand its functionality and facilitate product development.image |
| 资助项目 | Y.S. gratefully acknowledges support from the National Natural Science Foundation of China (grant 12172359), Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (ZDBS-LY-JSC014), and CAS Interdisciplinary Innovation Team (JCTD-2020[12172359] ; National Natural Science Foundation of China[ZDBS-LY-JSC014] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences[JCTD-2020-03] ; CAS Interdisciplinary Innovation Team |
| WOS关键词 | HUMAN STRATUM-CORNEUM ; HIGH-VOLTAGE ; TRANSPORT REGIONS ; ULTRASOUND ; MICRONEEDLES ; SILICONE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001105679100001 |
| 资助机构 | Y.S. gratefully acknowledges support from the National Natural Science Foundation of China (grant 12172359), Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (ZDBS-LY-JSC014), and CAS Interdisciplinary Innovation Team (JCTD-2020 ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; CAS Interdisciplinary Innovation Team |
| 内容类型 | 期刊论文 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/93493]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 通讯作者 | Su, Yewang |
| 作者单位 | 1.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Mech, State Key Lab High Temp Gas Dynam, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Mech, Key Lab Mech Fluid Solid Coupling Syst, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China 5.Chinese Acad Inspect & Quarantine, Cosmet Technol Ctr, Beijing 100176, Peoples R China 6.Capital Med Univ, Beijing Tongren Hosp, Dept Foot & Ankle Surg, Beijing 100730, Peoples R China 7.Univ Chinese Acad Sci, Beijing 101449, Peoples R China 8.Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China 9.Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China 10.Zhongke Carrying Equipment Technol Co, Beijing 101407, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xinkai,Guo, Liang,Liu, Hao,et al. Stretchable Electronic Facial Masks for Skin Electroporation[J]. ADVANCED FUNCTIONAL MATERIALS,2023:14. |
| APA | Xu, Xinkai.,Guo, Liang.,Liu, Hao.,Zhou, Zanxin.,Li, Shuang.,...&Su, Yewang.(2023).Stretchable Electronic Facial Masks for Skin Electroporation.ADVANCED FUNCTIONAL MATERIALS,14. |
| MLA | Xu, Xinkai,et al."Stretchable Electronic Facial Masks for Skin Electroporation".ADVANCED FUNCTIONAL MATERIALS (2023):14. |
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