Precise Localization and Simultaneous Bacterial Eradication of Biofilms Based on Nanocontainers with Successive Responsive Property toward pH and ATP

doi:10.1021/acsami.2c22682

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	Precise Localization and Simultaneous Bacterial Eradication of Biofilms Based on Nanocontainers with Successive Responsive Property toward pH and ATP
	Wang, Yingwen 1,2,3; Zhang, Dun 1,2,3; Sun, Yan 2,3; Zeng, Yan 2,3; Qi, Peng 1,2,3
刊名	ACS APPLIED MATERIALS & INTERFACES
	2023-02-06
页码	12
关键词	nanocontainers biofilm localization bacterial eradication amorphous calcium carbonate poly(acrylic acid)
ISSN号	1944-8244
DOI	10.1021/acsami.2c22682
通讯作者	Zhang, Dun(zhangdun@qdio.ac.cn) ; Qi, Peng(qipeng@qdio.ac.cn)
英文摘要	The bacterial colonization of surfaces and subsequent biofilm formation are a great threat in medical therapy and clinical diagnosis. The complex internal structure and composition sets an enormous obstacle for the localization and removal of biofilms. In this study, we proposed a novel biofilm-targeted nanocontainer with successive responsive property toward pH and ATP for precise localization and simultaneous bacterial eradication, with an acidic and adenosine triphosphate (ATP)-rich micro environment within biofilms, formed due to the accumulation of fatty acids and ATP in the three-dimensional enclosed structure, integrated as two successive indicators to improve the precision of biofilm identification and removal. The biofilm-targeted nano container was composed of a ATP-responsive zeolitic imidazolate framework-90 (ZIF-90) core loaded with Rho 6G and doxorubicin hydrochloride (DOX) encapsulated in the pH-responsive amorphous calcium carbonate/poly(acrylic acid) (ACC/PAA) shell. In the presence of biofilms, the ACC/PAA shell and ZIF-90 core were successively degraded by the accumulated H+ and ATP within biofilms, resulting in the release of fluorescence indicators and antimicrobial agents. On the other hand, to meet the application requirements of different biofilm scenarios, the pH response ability of the nanocontainers could be adjusted by changing the metallic ions (Ni2+, Zn2+, and Cu2+) doped into the structure of the ACC/PAA shell. Owing to excellent water dispersion of the pH/ATP double-responsive ZIF-90@Zn-ACC/PAA nanocontainer, precise localization and simultaneous bacterial eradication was successfully realized via a simple spray process. The successive pH/ ATP two-step unlocking processes endowed the nanocontainers high precision for localization and simultaneous eradication of biofilms, which made the proposed nanocontainers high promising in food safety and medical treatment.
资助项目	National Natural Science Foundation of China[41876101] ; National Natural Science Foundation of China[41906037] ; Nantong Scientific Plan Foundation[JC2021054] ; Nantong Scientific Plan Foundation[JC2020090]
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000928380500001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/183473]
专题	海洋研究所_海洋腐蚀与防护研究发展中心
通讯作者	Zhang, Dun; Qi, Peng
作者单位	1.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Marine Corros & Protect, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Environm Corros & Biofouling, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yingwen,Zhang, Dun,Sun, Yan,et al. Precise Localization and Simultaneous Bacterial Eradication of Biofilms Based on Nanocontainers with Successive Responsive Property toward pH and ATP[J]. ACS APPLIED MATERIALS & INTERFACES,2023:12.
APA	Wang, Yingwen,Zhang, Dun,Sun, Yan,Zeng, Yan,&Qi, Peng.(2023).Precise Localization and Simultaneous Bacterial Eradication of Biofilms Based on Nanocontainers with Successive Responsive Property toward pH and ATP.ACS APPLIED MATERIALS & INTERFACES,12.
MLA	Wang, Yingwen,et al."Precise Localization and Simultaneous Bacterial Eradication of Biofilms Based on Nanocontainers with Successive Responsive Property toward pH and ATP".ACS APPLIED MATERIALS & INTERFACES (2023):12.