Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis

doi:10.1016/j.bioorg.2022.106021

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis
	Hu, Xue-Yi 1,2,4; Li, Xiao-Ming 1,2; Liu, Hui 1,2; Wang, Bin-Gui 1,2,3,4; Meng, Ling-Hong 1,2,3
刊名	BIOORGANIC CHEMISTRY
	2022-11-01
卷号	128 页码:8
关键词	Penicillium chermesinum Comparative transcriptome analysis Meroterpenoids Antimicrobial activitie Plausible biosynthesis pathway
ISSN号	0045-2068
DOI	10.1016/j.bioorg.2022.106021
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn)
英文摘要	As the development of genetic and bioinformatic, the strategy of "bottom-up", combined with genome and transcriptome techniques, was considered as an efficient and practical method to break through the limitation of traditional discovery of natural products. Generally, comparative transcriptome analysis could be useful to guide the optimization of fungal cultivation conditions in which the transcriptional level of interesting compounds is higher. The transcriptome analysis of the algal endophytic fungus Penicillium chermesinum EN-480 indicated that fermentation of this fungus in modified rice solid medium could produce some metabolites different from those cultivated in other media. Four new meroterpenoids (compounds 1-4, namely, chermesins E-H) were characterized and their structures were determined by HRESIMS and NMR spectra. The absolute configurations were confirmed by NOESY experiments, X-ray diffraction analysis, and comparison of ECD cotton effects. Antimicrobial activities against human- and aqua-bacteria as well as against plant-pathogenic fungi were assayed. The plausible biosynthesis pathway of these compounds was discussed.
资助项目	National Natural Science Foundation of China[42176115] ; Laboratory of Marine Biology and Biotechnology of the Qingdao National Laboratory for Marine Science and Technology[YQ2018NO08]
WOS关键词	NATURAL-PRODUCTS ; FUNGUS ; BIOSYNTHESIS ; REVEALS ; PATHWAY ; GENE
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:001000178600001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/183213]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Meng, Ling-Hong
作者单位	1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao Natl Lab Marine Sci & Technol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China 4.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Hu, Xue-Yi,Li, Xiao-Ming,Liu, Hui,et al. Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis[J]. BIOORGANIC CHEMISTRY,2022,128:8.
APA	Hu, Xue-Yi,Li, Xiao-Ming,Liu, Hui,Wang, Bin-Gui,&Meng, Ling-Hong.(2022).Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis.BIOORGANIC CHEMISTRY,128,8.
MLA	Hu, Xue-Yi,et al."Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis".BIOORGANIC CHEMISTRY 128(2022):8.