Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis

doi:10.1039/d3np00023

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis
	Yan, Li-Hong 1,3,4; Li, Xin 1,2,4; Wang, Bin-Gui 1,2,3,4
刊名	NATURAL PRODUCT REPORTS
	2023-08-29
页码	27
ISSN号	0265-0568
DOI	10.1039/d3np00023
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
英文摘要	Covering: up to the end of July, 20231,2-Oxazine is a heterocyclic scaffold rarely found in natural products and is characterized by a directly connected N-O bond in a six-membered ring. Since the discovery of geneserine, the first 1,2-oxazine-containing natural product (1,2-oxazine NP) being isolated from Calabar bean (Physostigma venenosum) in 1925, a total of 76 naturally occurring 1,2-oxazine NPs have been isolated and identified from various sources, which have attracted the attention of researchers in the field of natural product chemistry, organic synthesis, biosynthesis, and pharmacology. This review summarizes the chemical family of 1,2-oxazine NPs, focusing on their source organisms, structural diversities, chemical synthesis, and biosynthesis. This review summarizes the chemical family of natural products with 1,2-oxazine scaffold, focusing on their source organisms, structural diversities, bioactivities, chemical synthesis, and biosynthesis.
资助项目	This work was financially supported by the National Natural Science Foundation of China (42076090 and U2006203), by the Shandong Provincial Natural Science Foundation (ZR2021ZD28 and ZR2019ZD18), and by the Senior User Project of RV KEXUE[U2006203] ; This work was financially supported by the National Natural Science Foundation of China (42076090 and U2006203), by the Shandong Provincial Natural Science Foundation (ZR2021ZD28 and ZR2019ZD18), and by the Senior User Project of RV KEXUE[ZR2021ZD28] ; National Natural Science Foundation of China[ZR2019ZD18] ; National Natural Science Foundation of China[KEXUE2020GZ02] ; Shandong Provincial Natural Science Foundation[2023216] ; National Major Science and Technology Infrastructure from Chinese Academy of Sciences ; Youth Innovation Promotion Association CAS ; [42076090]
WOS关键词	TRICHODERMA CF. BREVICOMPACTUM ; CYTOTOXIC MODIFIED DIPEPTIDES ; INTERSTRAND CROSS-LINKING ; MEK INHIBITOR RO4987655 ; CONCISE TOTAL-SYNTHESIS ; ENDOPHYTIC FUNGUS ; PENICILLIUM-JANTHINELLUM ; HETEROCYCLIC DIPEPTIDES ; ABSOLUTE-CONFIGURATION ; MONOTERPENOID INDOLE
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:001055975100001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/182900]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Yan, Li-Hong,Li, Xin,Wang, Bin-Gui. Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis[J]. NATURAL PRODUCT REPORTS,2023:27.
APA	Yan, Li-Hong,Li, Xin,&Wang, Bin-Gui.(2023).Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis.NATURAL PRODUCT REPORTS,27.
MLA	Yan, Li-Hong,et al."Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis".NATURAL PRODUCT REPORTS (2023):27.