Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata

doi:10.3390/molecules28114343

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata
	Wei, Sijie 3,4; Geng, Lihua 4; Yu, Haoyu 3,4; Wang, Jing 4; Yue, Yang 4; Zhang, Quanbin 3,4; Wu, Ning 1,2,4
刊名	MOLECULES
	2023-05-25
卷号	28 期号:11 页码:15
关键词	Costaria costata fucoidan idiopathic pulmonary fibrosis
DOI	10.3390/molecules28114343
通讯作者	Wu, Ning(wuning@qdio.ac.cn)
英文摘要	Pulmonary fibrosis is a chronic, progressive, and fatal disease of the interstitial lung. There is currently a lack of efficient therapy to reverse the prognosis of patients. In this study, a fucoidan from Costaria costata was isolated, and its anti-idiopathic fibrosis activity was investigated both in vitro and in vivo. The chemical composition analysis showed that C. costata polysaccharide (CCP) consists of galactose and fucose as the main monosaccharides with a sulfate group content of 18.54%. Further study found that CCP could resist TGF-beta 1-induced epithelial-mesenchymal transition (EMT) in A549 cells by inhibiting the TGF-beta/Smad and PI3K/AKT/mTOR signaling pathways. Moreover, in vivo study found that CCP treatment alleviated bleomycin (BLM)-stimulated fibrosis and inflammation in mice lung tissue. In conclusion, the present study suggests that CCP could protect the lung from fibrosis by relieving the EMT process and inflammation in lung cells.
资助项目	National Key R&D Program of China[2022YFD2401203] ; Nantong Science and Technology project[MS12021037]
WOS关键词	TGF-BETA/SMAD ; INDUCED EMT ; MODEL ; ACID
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:001003718200001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/182296]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wu, Ning
作者单位	1.Nantong Zhongke Marine Sci & Technol Res & Dev Ctr, Nantong 226682, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Drugs & Bioprod, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wei, Sijie,Geng, Lihua,Yu, Haoyu,et al. Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata[J]. MOLECULES,2023,28(11):15.
APA	Wei, Sijie.,Geng, Lihua.,Yu, Haoyu.,Wang, Jing.,Yue, Yang.,...&Wu, Ning.(2023).Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata.MOLECULES,28(11),15.
MLA	Wei, Sijie,et al."Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata".MOLECULES 28.11(2023):15.