Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles

doi:10.3390/polym15112510

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles
	Chen, Xuelian 2; Liu, Lijia 1; Shen, Chen 2; Liu, Fangyan 2; Xu, Enyu 2; Chen, Yin 2; Jie, Wang 2
刊名	POLYMERS
	2023-05-30
卷号	15 期号:11 页码:16
关键词	layer-by-layer nanoparticle polysaccharide
DOI	10.3390/polym15112510
通讯作者	Jie, Wang(011103@zjou.edu.cn)
英文摘要	In recent years, natural polysaccharides have been widely used in the preparation of drug delivery systems. In this paper, novel polysaccharide-based nanoparticles were prepared by layer-by-layer assembly technology using silica as a template. The layers of nanoparticles were constructed based on the electrostatic interaction between a new pectin named NPGP and chitosan (CS). The targeting ability of nanoparticles was formed by grafting the RGD peptide, a tri-peptide motif containing arginine, glycine, and aspartic acid with high affinity to integrin receptors. The layer-by-layer assembly nanoparticles (RGD-(NPGP/CS)(3)NPGP) exhibited a high encapsulation efficiency (83.23 +/- 6.12%), loading capacity (76.51 +/- 1.24%), and pH-sensitive release property for doxorubicin. The RGD-(NPGP/CS)(3)NPGP nanoparticles showed better targeting to HCT-116 cells, the integrin alpha v beta 3 high expression human colonic epithelial tumor cell line with higher uptake efficiency than MCF7 cells, the human breast carcinoma cell line with normal integrin expression. In vitro antitumor activity tests showed that the doxorubicin-loaded nanoparticles could effectively inhibit the proliferation of the HCT-116 cells. In conclusion, RGD-(NPGP/CS)(3)NPGP nanoparticles have potential as novel anticancer drug carriers because of their good targeting and drug-carrying activity.
资助项目	National Natural Science Foundation of Zhejiang Province, China[LTGS23D060001]
WOS关键词	HOLLOW NANOCAPSULES ; RELEASE
WOS研究方向	Polymer Science
语种	英语
出版者	MDPI
WOS记录号	WOS:001003459100001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/182293]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Jie, Wang
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Zhejiang Ocean Univ, Coll Food & Pharm, Zhoushan 316000, Peoples R China
推荐引用方式 GB/T 7714	Chen, Xuelian,Liu, Lijia,Shen, Chen,et al. Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles[J]. POLYMERS,2023,15(11):16.
APA	Chen, Xuelian.,Liu, Lijia.,Shen, Chen.,Liu, Fangyan.,Xu, Enyu.,...&Jie, Wang.(2023).Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles.POLYMERS,15(11),16.
MLA	Chen, Xuelian,et al."Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles".POLYMERS 15.11(2023):16.