Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512

doi:10.1021/acs.jafc.3c02610

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512
	Chi, Lu-Ping 2,3,4; Liu, Dong 2,3; Li, Xiao-Ming 2,3; Wan, Yupeng 2,3; Wang, Bin-Gui 1,2,3; Li, Xin 1,2,3
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2023-08-31
卷号	71 期号:36 页码:13316-13324
关键词	marine-derivedfungi pentadepsipeptides p-methoxycinnamoylamide Aspergillus spp. antimicrobial activity
ISSN号	0021-8561
DOI	10.1021/acs.jafc.3c02610
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Li, Xin(lixin@qdio.ac.cn)
英文摘要	Marine fungus-derived natural products are an important source of antimicrobial compounds against marine aquatic pathogens. Here, we describe the isolation and characterization of five new pentadepsipeptides, aspertides A-E (1-5), containing a unique p-methoxycinnamoyl amide group, from the marine fungi Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512. Among them, aspertides B-E (2-5) also possessed uncommon amino acid residues, such as 3-hydroxyproline, 2,3-dihydroxyproline, or pipecolinic acid. The structures of these compounds were elucidated on the basis of NMR and mass spectroscopic analyses. The absolute configurations of them were established by chiral HPLC analyses of the acidic hydrolysates and NMR calculations with DP4+ probability analysis. In bio-activity assays, compounds 4 and 5 exhibited antibacterial activities against aquatic-pathogenic bacteria, including Edwardsiella tarda, Vibrio alginolyticus, Vibrio anguillarum, Vibrio vulnificus, and Staphylococcus aureus, with MIC values of 8-32 mu g/mL.
资助项目	This work was financially supported by the National Key Ramp;amp;D Program of China (2022YFC2804700), the National Natural Science Foundation of China (32200022, 42076090, and U2006203), and the Shandong Provincial Natural Science Foundation (ZR2021ZD28).
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:001064234000001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/182071]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Li, Xin
作者单位	1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 4.Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Chi, Lu-Ping,Liu, Dong,Li, Xiao-Ming,et al. Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(36):13316-13324.
APA	Chi, Lu-Ping,Liu, Dong,Li, Xiao-Ming,Wan, Yupeng,Wang, Bin-Gui,&Li, Xin.(2023).Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(36),13316-13324.
MLA	Chi, Lu-Ping,et al."Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.36(2023):13316-13324.