Preliminary screening of biomarkers in HAPE based on quasi-targeted metabolomics

	Preliminary screening of biomarkers in HAPE based on quasi-targeted metabolomics
	Lin, Xue; Dai, Chongyang; Chen, Zhi; Zhang, Tongzuo; Pu, Xiaoyan
刊名	FRONTIERS IN PHYSIOLOGY
	2023
卷号	14
英文摘要	High altitude pulmonary edema (HAPE) is a serious threat to the physical and mental health of people who quickly enter high plateaus, deserves more attention and in-depth research. In our study, through the detection of various physiological indexes and other phenotypes in a HAPE rat model, the HAPE group showed a significant decrease in oxygen partial pressure and oxygen saturation, and a significant increase in pulmonary artery pressure and lung tissue water content. The lung histomorphology showed characteristics such as pulmonary interstitial thickening and inflammatory cell infiltration. We applied quasi-targeted metabolomics to compare and analyze the components of metabolites in arterial-veinous blood in control rats and HAPE rats. Using kyoto Encyclopedia of Genes Genomes (KEGG) enrichment analysis and two machine algorithms, we speculate that after hypoxic stress and comparing arterial blood and venous blood products in rats, the metabolites were richer, indicating that normal physiological activities, such as metabolism and pulmonary circulation had a greater impact after hypoxic stress; D-mannose(DOWN), oxidized glutathione(DOWN), glutathione disulfide(DOWN), and dehydrocholic acid(DOWN) in arterial blood play key roles in predicting the occurrence of HAPE; in venous blood, L-leucine(DOWN), L-thyroxine(DOWN), and cis-4-hydroxy- D-proline(DOWN) may have key roles, which can be considered biomarkers of HAPE. This result provides a new perspective for the further diagnosis and treatment of plateau disease and lays a strong foundation for further research.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/61682]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Lin, Xue,Dai, Chongyang,Chen, Zhi,et al. Preliminary screening of biomarkers in HAPE based on quasi-targeted metabolomics[J]. FRONTIERS IN PHYSIOLOGY,2023,14.
APA	Lin, Xue,Dai, Chongyang,Chen, Zhi,Zhang, Tongzuo,&Pu, Xiaoyan.(2023).Preliminary screening of biomarkers in HAPE based on quasi-targeted metabolomics.FRONTIERS IN PHYSIOLOGY,14.
MLA	Lin, Xue,et al."Preliminary screening of biomarkers in HAPE based on quasi-targeted metabolomics".FRONTIERS IN PHYSIOLOGY 14(2023).