Preparation of a Dual-Functional Sulfated Galactofucan Polysaccharide/Poly(vinyl alcohol) Hydrogel to Promote Macrophage Recruitment and Angiogenic Potential in Diabetic Wound Healing

doi:10.1021/acs.biomac.3c00569

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Preparation of a Dual-Functional Sulfated Galactofucan Polysaccharide/Poly(vinyl alcohol) Hydrogel to Promote Macrophage Recruitment and Angiogenic Potential in Diabetic Wound Healing
	Liu, Yang 3,4,5; Deng, Zhenzhen 2,4,5; Zhang, Jingjing 1; Wu, Yumeng 2,4,5; Wu, Ning 4,5; Geng, Lihua 2,4,5; Yue, Yang 2,4,5; Zhang, Quanbin 2,4,5; Wang, Jing 2,4,5
刊名	BIOMACROMOLECULES
	2023-09-07
页码	12
ISSN号	1525-7797
DOI	10.1021/acs.biomac.3c00569
通讯作者	Wang, Jing(jingwang@qdio.ac.cn)
英文摘要	A diabetic foot ulcer is a common high-risk complication in diabetic patients, but there is still no universal dressing for clinical treatment. In this study, a novel dual-functional sulfated galactofucan polysaccharide/poly(vinyl alcohol) hydrogel (DPH20) is developed during freeze-thaw cycles. Experimental results indicated that DPH20 had a high specific surface area, a dense porous structure, and a good swelling property, which could effectively adsorb the exudates and keep the wound moist. Furthermore, DPH20 exhibited remarkably recruited macrophage capability and accelerated the inflammation stage by improving the expression of the mRNA of CCL2, CCR2, and CCL22 in macrophages. DPH20 could promote cell migration and growth factor release to accelerate tube formation under hyperglycemic conditions in cell models of L929s and HUEVCs, respectively. Significantly, DPH20 accelerates the reconstruction of the full-thickness skin wound by accelerating the recruitment of macrophages, promoting angiogenesis, and releasing the growth factor in the diabetic mouse model. Collectively, DPH20 is a promising multifunctional dressing to reshape the damaged tissue environment and accelerate wound healing. This study provides an efficient strategy to repair and regenerate diabetic skin ulcers.
资助项目	Natural Science Foundation of China (NSFC)[41406144] ; Shandong Provincial Natural Science Foundation[ZR2022MD007] ; Science and Technology project of Fujian Province[2022T3024]
WOS关键词	FUCOIDAN ; INJURY
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:001066576000001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/181664]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wang, Jing
作者单位	1.Qingdao Eighth Peoples Hosp, Qingdao 266121, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Qingdao Univ, Coll Mat Sci & Engn, Qingdao 266003, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yang,Deng, Zhenzhen,Zhang, Jingjing,et al. Preparation of a Dual-Functional Sulfated Galactofucan Polysaccharide/Poly(vinyl alcohol) Hydrogel to Promote Macrophage Recruitment and Angiogenic Potential in Diabetic Wound Healing[J]. BIOMACROMOLECULES,2023:12.
APA	Liu, Yang.,Deng, Zhenzhen.,Zhang, Jingjing.,Wu, Yumeng.,Wu, Ning.,...&Wang, Jing.(2023).Preparation of a Dual-Functional Sulfated Galactofucan Polysaccharide/Poly(vinyl alcohol) Hydrogel to Promote Macrophage Recruitment and Angiogenic Potential in Diabetic Wound Healing.BIOMACROMOLECULES,12.
MLA	Liu, Yang,et al."Preparation of a Dual-Functional Sulfated Galactofucan Polysaccharide/Poly(vinyl alcohol) Hydrogel to Promote Macrophage Recruitment and Angiogenic Potential in Diabetic Wound Healing".BIOMACROMOLECULES (2023):12.