A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides | |
Zhang, Fan-Zhong3,4; Li, Xiao-Ming3,4; Meng, Ling-Hong1,2,3,4; Wang, Bin-Gui1,2,3,4 | |
刊名 | JOURNAL OF ANTIBIOTICS |
2023-10-26 | |
页码 | 8 |
ISSN号 | 0021-8820 |
DOI | 10.1038/s41429-023-00666-3 |
通讯作者 | Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
英文摘要 | Three new compounds, including one steroid named penivariod A (1) and two polyketides penivarides A and B (2 and 3), as well as six known derivatives (4-9) were isolated from Penicillium variabile EN-394, a fungus afforded from the marine red alga Rhodomela confervoides. Their structures were elucidated by analysis of the HRESIMS, 1D and 2D NMR. The absolute stereochemistry was determined by X-ray crystallographic data, gauge-independent atomic orbital (GIAO) NMR shift calculation followed by DP4+ analysis combined with calculated electronic circular dichroism (ECD). Antimicrobial activities for the new compounds (1-3) were evaluated against human-and aquatic-pathogenic bacteria as well as plant pathogenic fungi. Compound 1 exhibited potent antimicrobial activity against most of the pathogenic strains, especially for Escherichia coli and Pseudomonas aeruginosa, with MIC values of 1.0 and 2.0 mu g ml(-1), respectively. |
资助项目 | Financial support from the National Natural Science Foundation of China (31600267 and 42176115) and from the Natural Science Foundation of Jiangsu Province (No. BK20201211) is gratefully acknowledged.[31600267] ; Financial support from the National Natural Science Foundation of China (31600267 and 42176115) and from the Natural Science Foundation of Jiangsu Province (No. BK20201211) is gratefully acknowledged.[42176115] ; National Natural Science Foundation of China[BK20201211] ; Natural Science Foundation of Jiangsu Province |
WOS关键词 | A-D ; ASPERGILLUS |
WOS研究方向 | Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | SPRINGERNATURE |
WOS记录号 | WOS:001089669800001 |
内容类型 | 期刊论文 |
源URL | [http://ir.qdio.ac.cn/handle/337002/181558] |
专题 | 海洋研究所_实验海洋生物学重点实验室 |
通讯作者 | Meng, Ling-Hong; Wang, Bin-Gui |
作者单位 | 1.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Fan-Zhong,Li, Xiao-Ming,Meng, Ling-Hong,et al. A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides[J]. JOURNAL OF ANTIBIOTICS,2023:8. |
APA | Zhang, Fan-Zhong,Li, Xiao-Ming,Meng, Ling-Hong,&Wang, Bin-Gui.(2023).A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides.JOURNAL OF ANTIBIOTICS,8. |
MLA | Zhang, Fan-Zhong,et al."A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides".JOURNAL OF ANTIBIOTICS (2023):8. |
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