The Effects of Low Dose Ketamine on Working Memory

doi:10.16476/j.pibb.2022.0195

CORC > 自动化研究所 > 中国科学院自动化研究所 > 脑图谱与类脑智能实验室

	The Effects of Low Dose Ketamine on Working Memory
	Zhao Zhi-Ping 3,6; Nie Chuang 5; Jiang Cheng-Teng 2; Luo Wei-Wei 5; Gu Jian-Wen 5; Yu Shan 1,4
刊名	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
	2023-03-01
卷号	50 期号:3 页码:473-485
关键词	low-dose ketamine working memory NMDA receptors acute effect chronic effect
ISSN号	1000-3282
DOI	10.16476/j.pibb.2022.0195
通讯作者	Gu Jian-Wen(jiuwufushou@qq.com) ; Yu Shan(shan.yu@nlpr.ia.ac.cn)
英文摘要	Ketamine is an NMDAR antagonist that has been widely used for clinical anesthesia. In addition, low-dose ketamine has analgesic, anti-inflammatory and antidepressant effects, which have attracted extensive attention in recent years. However, how low-dose ketamine can affect the higher cognitive functions remain unclear. Here we review the effects of low-dose ketamine on working memory (WM). WM is the ability to temporally hold and manipulate information in the brain. It mainly relies on a network involving several key brain areas such as the prefrontal cortex (PFC), hippocampus, etc. WM plays a key role in many complex cognitive processes, thus to understand how it may be affected by low-dose ketamine is informative and important for its clinic use. Here we review the studies showing that acute or chronic use of low-dose ketamine will impair working memory in a sophisticated way. The possible mechanisms underlying such impairments include breaking the excitation/inhibition (E/I) balance in the PFC, changing the short-term and long-term synaptic plasticity, activating the DA pathway, etc. We also pointed out that to fully reveal the effects of low-dose ketamine on WM and related neural mechanism, future multi-facet studies combining behavioral tests, electrophysiology, neuroimaging, histology, etc, and with more comparable dosage and time of medication would be needed. We hope that this review will be instrumental for facilitating appropriate use of low-dose ketamine in clinical settings.
资助项目	National Key Research and Development Program of China[2017YFA0105203] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32040200]
WOS关键词	PREFRONTAL CORTEX ; ANTIDEPRESSANT ACTIONS ; COGNITIVE IMPAIRMENTS ; DOPAMINERGIC FUNCTION ; ANTAGONISTS KETAMINE ; NMDA RECEPTORS ; DEPRESSION ; INCREASES ; PROFILE ; MODEL
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
WOS记录号	WOS:001054480300005
资助机构	National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/54131]
专题	脑图谱与类脑智能实验室
通讯作者	Gu Jian-Wen; Yu Shan
作者单位	1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 101408, Peoples R China 3.Jilin Univ, Hosp 1, Changchun 130021, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Strateg Support Force Med Ctr, Beijing 100101, Peoples R China 6.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Zhao Zhi-Ping,Nie Chuang,Jiang Cheng-Teng,et al. The Effects of Low Dose Ketamine on Working Memory[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2023,50(3):473-485.
APA	Zhao Zhi-Ping,Nie Chuang,Jiang Cheng-Teng,Luo Wei-Wei,Gu Jian-Wen,&Yu Shan.(2023).The Effects of Low Dose Ketamine on Working Memory.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,50(3),473-485.
MLA	Zhao Zhi-Ping,et al."The Effects of Low Dose Ketamine on Working Memory".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 50.3(2023):473-485.