Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex

doi:10.1038/s41398-023-02616-x

CORC > 自动化研究所 > 中国科学院自动化研究所 > 脑图谱与类脑智能实验室

	Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex
	Shao, Tiannan 2,3; Huang, Jing 2,3; Zhao, Yuxin 4,5,6; Wang, Weiyan 2,3; Tian, Xiaohan 7; Hei, Gangrui 8; Kang, Dongyu 2,3; Gao, Yong 9; Liu, Fangkun 10; Zhao, Jingping 2,3
刊名	TRANSLATIONAL PSYCHIATRY
	2023-10-11
卷号	13 期号:1 页码:10
ISSN号	2158-3188
DOI	10.1038/s41398-023-02616-x
通讯作者	Wu, Renrong(wurenrong@csu.edu.cn)
英文摘要	Cognitive impairment is a core feature of schizophrenia, which is aggravated by antipsychotics-induced metabolic disturbance and lacks effective pharmacologic treatments in clinical practice. Our previous study demonstrated the efficiency of metformin in alleviating metabolic disturbance following antipsychotic administration. Here we report that metformin could ameliorate cognitive impairment and improve functional connectivity (FC) in prefrontal regions. This is an open-labeled, evaluator-blinded study. Clinically stable patients with schizophrenia were randomly assigned to receive antipsychotics plus metformin (N = 48) or antipsychotics alone (N = 24) for 24 weeks. The improvement in cognition was assessed by the MATRICS Consensus Cognitive Battery (MCCB). Its association with metabolic measurements, and voxel-wise whole-brain FC with dorsolateral prefrontal cortex (DLPFC) subregions as seeds were evaluated. When compared to the antipsychotics alone group, the addition of metformin resulted in significantly greater improvements in the MCCB composite score, speed of processing, working memory, verbal learning, and visual learning. A significant time x group interaction effect of increased FC between DLPFC and the anterior cingulate cortex (ACC)/middle cingulate cortex (MCC), and between DLPFC subregions were observed after metformin treatment, which was positively correlated with MCCB cognitive performance. Furthermore, the FC between left DLPFC A9/46d to right ACC/MCC significantly mediated metformin-induced speed of processing improvement; the FC between left A46 to right ACC significantly mediated metformin-induced verbal learning improvement. Collectively, these findings demonstrate that metformin can improve cognitive impairments in schizophrenia patients and is partly related to the FC changes in the DLPFC. Trial Registration: The trial was registered with ClinicalTrials.gov (NCT03271866). The full trial protocol is provided in Supplementary Material.
资助项目	This work was supported by the National Natural Science Foundation of China (Grant Nos. 81622018 and 82072096).[81622018] ; This work was supported by the National Natural Science Foundation of China (Grant Nos. 81622018 and 82072096).[82072096] ; National Natural Science Foundation of China
WOS关键词	DOUBLE-BLIND ; DRUG-NAIVE ; BRAIN ; 1ST-EPISODE ; DYSFUNCTION ; WEIGHT ; RISK ; LIFE
WOS研究方向	Psychiatry
语种	英语
出版者	SPRINGERNATURE
WOS记录号	WOS:001079330300001
资助机构	This work was supported by the National Natural Science Foundation of China (Grant Nos. 81622018 and 82072096). ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/53041]
专题	脑图谱与类脑智能实验室
通讯作者	Wu, Renrong
作者单位	1.Nantong Univ, Minist Educ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China 2.Central South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Changsha, Peoples R China 3.Cent South Univ, Xiangya Hosp 2, Natl Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China 4.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 6.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 7.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 8.Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou 450052, Peoples R China 9.Cent South Univ, Changde Hosp, Peoples Hosp Changde 1, Xiangya Med Coll ,Dept Orthoped, Changde 415900, Peoples R China 10.Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Peoples R China
推荐引用方式 GB/T 7714	Shao, Tiannan,Huang, Jing,Zhao, Yuxin,et al. Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex[J]. TRANSLATIONAL PSYCHIATRY,2023,13(1):10.
APA	Shao, Tiannan.,Huang, Jing.,Zhao, Yuxin.,Wang, Weiyan.,Tian, Xiaohan.,...&Wu, Renrong.(2023).Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex.TRANSLATIONAL PSYCHIATRY,13(1),10.
MLA	Shao, Tiannan,et al."Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex".TRANSLATIONAL PSYCHIATRY 13.1(2023):10.