Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging

doi:10.1002/wsbm.1612

CORC > 自动化研究所 > 中国科学院自动化研究所 > 多模态人工智能系统全国重点实验室

	Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging
	Li, Wenjing 1,6; Pang, Yiyun 5; Jin, Kehan 5; Wang, Yuru 5; Wu, Yujie 6; Luo, Jichang 3,4; Xu, Wenlong 3,4; Zhang, Xiao 3,4; Xu, Ran 3,4; Wang, Tao 3,4
刊名	WIRES MECHANISMS OF DISEASE
	2023-05-08
页码	24
关键词	cardiovascular diseases cellular organelles cholesterol membrane contact sites vascular aging
ISSN号	2692-9368
DOI	10.1002/wsbm.1612
通讯作者	Xu, Ran(xrqssq@126.com) ; Wang, Tao(wangtao_dr@sina.com) ; Jiao, Liqun(liqunjiao@sina.cn)
英文摘要	Chronological age causes structural and functional vascular deterioration and is a well-established risk factor for the development of cardiovascular diseases, leading to more than 40% of all deaths in the elderly. The etiology of vascular aging is complex; a significant impact arises from impaired cholesterol homeostasis. Cholesterol level is balanced through synthesis, uptake, transport, and esterification, the processes executed by multiple organelles. Moreover, organelles responsible for cholesterol homeostasis are spatially and functionally coordinated instead of isolated by forming the membrane contact sites. Membrane contact, mediated by specific protein-protein interaction, pulls opposing organelles together and creates the hybrid place for cholesterol transfer and further signaling. The membrane contact-dependent cholesterol transfer, together with the vesicular transport, maintains cholesterol homeostasis and has intimate implications in a growing list of diseases, including vascular aging-related diseases. Here, we summarized the latest advances regarding cholesterol homeostasis by highlighting the membrane contact-based regulatory mechanism. We also describe the downstream signaling under cholesterol homeostasis perturbations, prominently in cholesterol-rich conditions, stimulating age-dependent organelle dysfunction and vascular aging. Finally, we discuss potential cholesterol-targeting strategies for therapists regarding vascular aging-related diseases.This article is categorized under:Cardiovascular Diseases > Molecular and Cellular Physiology
资助项目	Beijing Municipal Science & Technology Commission[5202022] ; National Natural Science Foundation of China[82171303] ; National Natural Science Foundation of China[91954201]
WOS关键词	FOAM CELL-FORMATION ; COOPERATIVE BINDING ; NLRP3 INFLAMMASOME ; RECEPTOR ; TRANSPORT ; MITOCHONDRIA ; ACTIVATION ; MECHANISMS ; ER ; ATHEROSCLEROSIS
WOS研究方向	Research & Experimental Medicine
语种	英语
出版者	WILEY
WOS记录号	WOS:000985049100001
资助机构	Beijing Municipal Science & Technology Commission ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/53209]
专题	多模态人工智能系统全国重点实验室
通讯作者	Xu, Ran; Wang, Tao; Jiao, Liqun
作者单位	1.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 2.Capital Med Univ, Xuanwu Hosp, Dept Intervent Radiol, Beijing, Peoples R China 3.China Int Neurosci Inst China INI, Beijing, Peoples R China 4.Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China 5.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Automat, Lab Computat Biol & Machine Intelligence, Natl Lab Pattern Recognit, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Wenjing,Pang, Yiyun,Jin, Kehan,et al. Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging[J]. WIRES MECHANISMS OF DISEASE,2023:24.
APA	Li, Wenjing.,Pang, Yiyun.,Jin, Kehan.,Wang, Yuru.,Wu, Yujie.,...&Jiao, Liqun.(2023).Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging.WIRES MECHANISMS OF DISEASE,24.
MLA	Li, Wenjing,et al."Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging".WIRES MECHANISMS OF DISEASE (2023):24.