State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex

doi:10.1016/j.brs.2023.07.049

	State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex
	Cao, Dan 3; Liu, Qihong 5; Zhang, Jiaqi 3,4; Li, Jin 2; Jiang, Tianzi 1,3,4
刊名	BRAIN STIMULATION
	2023-07-01
卷号	16 期号:4 页码:1112-1122
关键词	Intracranial electrical stimulation Orbitofrontal cortex State-specific modulation Emotional network Intracranial EEG
ISSN号	1935-861X
DOI	10.1016/j.brs.2023.07.049
通讯作者	Li, Jin(jli@nlpr.ia.ac.cn) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要	Background: Orbitofrontal cortex (OFC) is a promising target for intracranial electrical stimulation (iES) aimed at improving mood states. However, knowledge gaps remain regarding the underlying neural mechanisms of iES effects, such as the effect of the OFC target in comparison with other emotional network targets, the impact of brain state at the time of stimulation, and the neural response induced by iES at both local and network scales. Objective: Our study aims to address the neural mechanisms underlying the effects of iES in improving mood states. Methods: We conducted a study in 24 epilepsy patients who received iES through implanted electrodes in the emotional network and compared the effects of iES on multiple targets in the emotional network. Results: We found that only iES applied to the orbitofrontal cortex (OFC) led to mood improvement and changes in neural activity. We also observed that iES to the OFC suppressed the delta-theta power when the brain was in a low mood state. Moreover, the iES to the OFC decreased delta-theta power and increased gamma power at local regions within the emotional network, and enhanced the information flow through the frequency domain among regions within the emotional network. Conclusions: These findings provide insight into the neural correlates of iES-induced mood improvement and support the potential of iES as a therapeutic intervention for mood disorders.
资助项目	STI2030-Major Projects[32271085] ; National Natural Science Foundation of China[82151307] ; National Natural Science Foundation of China[CNLYB2004] ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning[2022KI0AC02] ; Key Research Project of Zhejiang Lab[2022ND0AN01] ; [2021ZD0200200]
WOS关键词	PROBABILISTIC FUNCTIONAL TRACTOGRAPHY ; CIRCUITS ; EMOTION ; REWARD
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:001057252300001
资助机构	STI2030-Major Projects ; National Natural Science Foundation of China ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning ; Key Research Project of Zhejiang Lab
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/54068]
专题	自动化研究所_脑网络组研究中心
通讯作者	Li, Jin; Jiang, Tianzi
作者单位	1.Zhejiang Lab, Res Ctr Augmented Intelligence, Hangzhou 311100, Peoples R China 2.Capital Normal Univ, Sch Psychol, Beijing 100048, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Peoples R China
推荐引用方式 GB/T 7714	Cao, Dan,Liu, Qihong,Zhang, Jiaqi,et al. State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex[J]. BRAIN STIMULATION,2023,16(4):1112-1122.
APA	Cao, Dan,Liu, Qihong,Zhang, Jiaqi,Li, Jin,&Jiang, Tianzi.(2023).State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex.BRAIN STIMULATION,16(4),1112-1122.
MLA	Cao, Dan,et al."State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex".BRAIN STIMULATION 16.4(2023):1112-1122.