Preparation of imidazole acids grafted chitosan with enhanced antioxidant, antibacterial and antitumor activities

doi:10.1016/j.carbpol.2023.120978

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Preparation of imidazole acids grafted chitosan with enhanced antioxidant, antibacterial and antitumor activities
	Ma, Bing 1,2,3; Zhang, Jingjing 1,3; Mi, Yingqi 1,3; Miao, Qin 1,2,3; Tan, Wenqiang 1,3; Guo, Zhanyong 1,2,3
刊名	CARBOHYDRATE POLYMERS
	2023-09-01
卷号	315 页码:16
关键词	Imidazole acids grafted chitosan Antioxidant activity Antibacterial activity Antitumor activity
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2023.120978
通讯作者	Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	Herein, imidazole acids grafted chitosan derivatives were synthesized, including HACC, HACC derivatives, TMC, TMC derivatives, amidated chitosan and amidated chitosan bearing imidazolium salts. The prepared chitosan derivatives were characterized by FT-IR and 1H NMR. The tests evaluated the biological antioxidant, antibac-terial, and cytotoxic activities of chitosan derivatives. The antioxidant capacity (DPPH radical, superoxide anion radical and hydroxyl radical) of chitosan derivatives was 2.4-8.3 times higher than that of chitosan. The anti-bacterial capacity against E. coli and S. aureus of cationic derivatives (HACC derivatives, TMC derivatives, and amidated chitosan bearing imidazolium salts) was more active than only imidazole-chitosan (amidated chitosan). In particular, the inhibition effect of HACC derivatives on E. coli was 15.625 mu g/mL. Moreover, the series of chitosan derivatives bearing imidazole acids showed certain activity against MCF-7 and A549 cells. The present results suggest that the chitosan derivatives in this paper seem to be promising carrier materials for use in drug delivery systems.
WOS关键词	NANOPARTICLES ; HYDROGEL
WOS研究方向	Chemistry ; Polymer Science
语种	英语
WOS记录号	WOS:001001383700001
资助机构	Shandong Key R & D Plan, Major Scientific and Technological Innovation Project ; Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province of China ; Science & Technology Specific Projects in Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/32962]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Ma, Bing,Zhang, Jingjing,Mi, Yingqi,et al. Preparation of imidazole acids grafted chitosan with enhanced antioxidant, antibacterial and antitumor activities[J]. CARBOHYDRATE POLYMERS,2023,315:16.
APA	Ma, Bing,Zhang, Jingjing,Mi, Yingqi,Miao, Qin,Tan, Wenqiang,&Guo, Zhanyong.(2023).Preparation of imidazole acids grafted chitosan with enhanced antioxidant, antibacterial and antitumor activities.CARBOHYDRATE POLYMERS,315,16.
MLA	Ma, Bing,et al."Preparation of imidazole acids grafted chitosan with enhanced antioxidant, antibacterial and antitumor activities".CARBOHYDRATE POLYMERS 315(2023):16.