Comparative Proteome and Cis-Regulatory Element Analysis Reveals Specific Molecular Pathways Conserved in Dog and Human Brains

doi:10.1016/j.mcpro.2022.100261

	Comparative Proteome and Cis-Regulatory Element Analysis Reveals Specific Molecular Pathways Conserved in Dog and Human Brains
	Hong, Huilin 1; Zhao, Zhiguang 1,2,10; Huang, Xiahe 1; Guo, Chao 3,4; Zhao, Hui 1; Wang, Guo-Dong 4,5; Zhang, Ya-Ping 4,5; Zhao, Jian-Ping 6; Shi, Jianhui 7,8; Wu, Qing-Feng 1,2
刊名	MOLECULAR & CELLULAR PROTEOMICS
	2022-08-01
卷号	21 期号:8 页码:16
DOI	10.1016/j.mcpro.2022.100261
英文摘要	Brain development and function are governed by precisely regulated protein expressions in different regions. To date, multiregional brain proteomes have been systematically analyzed only for adult human and mouse brains. To un-derstand the underpinnings of brain development and function, we generated proteomes from six regions of the postnatal brain at three developmental stages of domestic dogs (Canis familiaris), which are special among animals in terms of their remarkable human-like social cognitive abilities. Quantitative analysis of the spatiotemporal pro-teomes identified region-enriched synapse types at different developmental stages and differential myelina-tion progression in different brain regions. Through inte-grative analysis of inter-regional expression patterns of orthologous proteins and genome-wide cis-regulatory element frequencies, we found that proteins related with myelination and hippocampus were highly correlated be-tween dog and human but not between mouse and human, although mouse is phylogenetically closer to human. Moreover, the global expression patterns of neurodegen-erative disease and autism spectrum disorder-associated proteins in dog brain more resemble human brain than in mouse brain. The high similarity of myelination and hippocampus-related pathways in dog and human at both proteomic and genetic levels may contribute to their shared social cognitive abilities. The inter-regional expression patterns of disease-associated proteins in the brain of different species provide important information to guide mechanistic and translational study using appropriate animal models.
资助项目	National Key Research and Development Program[2019YFA0707100] ; National Key Research and Development Program[2021ZD0203901] ; Strategic Priority Research Program B of the Chinese Academy of Sciences[XDBS1020100] ; National Science Foundation of China[31830036] ; National Science Foundation of China[31921002] ; National Science Foundation of China[32170679] ; National Science Foundation of China[11871462] ; Innovative Research Team (in Science and Technology) of Yunnan Province[201905E160019] ; Key Research Program of Frontier Sciences of the CAS[ZDBS-LY-SM011]
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000831113500003
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/61163]
专题	中国科学院数学与系统科学研究院
通讯作者	Zhang, Yong Q.; Xiong, Ying
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol & Dev Biol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 3.Univ Sci & Technol China, Sch Life Sci, Div Life Sci & Med, Hefei, Peoples R China 4.Chinese Acad Sci, State Key Lab Genet Resources & Evolut, Kunming Inst Zool, Kunming, Yunnan, Peoples R China 5.Chinese Acad Sci, Kunming Inst Zool, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China 6.Beijing Sinogene Biotechnol Co Ltd, Beijing, Peoples R China 7.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing, Peoples R China 8.Univ Chinese Acad Sci, Sch Math Sci, Beijing, Peoples R China 9.Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA 10.Hebei Ind Technol Res Inst Genom Maternal & Child, Shijiazhuang 050000, Hebei, Peoples R China
推荐引用方式 GB/T 7714	Hong, Huilin,Zhao, Zhiguang,Huang, Xiahe,et al. Comparative Proteome and Cis-Regulatory Element Analysis Reveals Specific Molecular Pathways Conserved in Dog and Human Brains[J]. MOLECULAR & CELLULAR PROTEOMICS,2022,21(8):16.
APA	Hong, Huilin.,Zhao, Zhiguang.,Huang, Xiahe.,Guo, Chao.,Zhao, Hui.,...&Xiong, Ying.(2022).Comparative Proteome and Cis-Regulatory Element Analysis Reveals Specific Molecular Pathways Conserved in Dog and Human Brains.MOLECULAR & CELLULAR PROTEOMICS,21(8),16.
MLA	Hong, Huilin,et al."Comparative Proteome and Cis-Regulatory Element Analysis Reveals Specific Molecular Pathways Conserved in Dog and Human Brains".MOLECULAR & CELLULAR PROTEOMICS 21.8(2022):16.