Unruptured brain arteriovenous malformations causing seizures localize to one common brain network

doi:10.1002/jnr.25142

	Unruptured brain arteriovenous malformations causing seizures localize to one common brain network
	Zhao, Shao-Zhi 6,7; Zhao, Yu-Xin 3,4,5; Liao, Xiao-Hua 3,4,5; Huo, Ran 6,7; Li, Hao 6,7; Jiao, Yu-Ming 6,7; Weng, Jian-Cong 6,7; Wang, Jie 6,7; Liu, Bing 1,2; Cao, Yong 6,7
刊名	JOURNAL OF NEUROSCIENCE RESEARCH
	2022-11-07
页码	11
关键词	brain arteriovenous malformations lesion network mapping seizures voxel-based lesion-symptom mapping
ISSN号	0360-4012
DOI	10.1002/jnr.25142
通讯作者	Liu, Bing(bing.liu@bnu.edu.cn) ; Cao, Yong(caoyong@bjtth.org)
英文摘要	Seizures are a frequent symptom of unruptured brain arteriovenous malformations (bAVMs). However, the brain regions responsible for these seizures remain unclear. To identify the brain regions causally involved in bAVM-related seizures, we retrospectively reviewed 220 patients with unruptured bAVMs. Using voxel-based lesion-symptom mapping (VLSM) analyses, we tested whether individual brain regions were associated with unruptured bAVM-related seizures. The result revealed that unruptured bAVMs causing seizures are anatomically heterogeneous at the voxel level. Subsequently, lesion network mapping (LNM) analyses was performed to determine whether bAVMs causing seizures belonged to a distributed brain network. LNM analyses indicated that these lesions were located in a functional network characterized by connectivity to the left caudate and precuneus. Moreover, the discrimination performance of the identified seizure network was evaluated in discovery set by calculating the individualized network damage score and was tested in validation set. Based on the calculated network damage scores, patients were divided into low-, medium-, and high-risk groups. The prevalence of seizures significantly differed among the three risk categories in both discovery (p = .003) and validation set (p = .004). Finally, we calculated the percentage of voxels in the canonical resting-state networks that overlapped with the seizure-susceptible brain regions to investigate the involvement of resting-state networks. With an involvement percentage over 50%, the frontoparietal control (82.9%), limbic function (76.7%), and default mode network (69.3%) were considered to be impacted in bAVM-related seizures. Our study identified the seizure-susceptible brain regions for unruptured bAVMs, which could be a plausible neuroimaging biomarker in predicting possible seizures.
资助项目	National key research and development program of China during the 13th Five-Year Plan Period[2016YFC1301803]
WOS关键词	DEFAULT MODE NETWORK ; INTERNATIONAL-LEAGUE ; EPILEPSY ; ILAE ; ABNORMALITIES
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	WILEY
WOS记录号	WOS:000879711500001
资助机构	National key research and development program of China during the 13th Five-Year Plan Period
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/50672]
专题	自动化研究所_脑网络组研究中心
通讯作者	Liu, Bing; Cao, Yong
作者单位	1.Chinese Inst Brain Res, Beijing, Peoples R China 2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 3.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 4.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China 5.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China 6.China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China 7.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, 119 South Fourth Ring Rd West, Beijing 100070, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Shao-Zhi,Zhao, Yu-Xin,Liao, Xiao-Hua,et al. Unruptured brain arteriovenous malformations causing seizures localize to one common brain network[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2022:11.
APA	Zhao, Shao-Zhi.,Zhao, Yu-Xin.,Liao, Xiao-Hua.,Huo, Ran.,Li, Hao.,...&Cao, Yong.(2022).Unruptured brain arteriovenous malformations causing seizures localize to one common brain network.JOURNAL OF NEUROSCIENCE RESEARCH,11.
MLA	Zhao, Shao-Zhi,et al."Unruptured brain arteriovenous malformations causing seizures localize to one common brain network".JOURNAL OF NEUROSCIENCE RESEARCH (2022):11.