A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents

doi:10.1007/s12264-022-00964-0

CORC > 自动化研究所 > 中国科学院自动化研究所 > 综合信息系统研究中心 > 脑机融合与认知评估

	A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents
	Qu, Xue-Tong 3,4,5; Wu, Jin-Ni 3,4,5; Wen, Yunqing 5; Chen, Long 5; Lv, Shi-Lei 2; Liu, Li 2; Zhan, Li-Jie 5; Liu, Tian-Yi 1; He, Hua 1; Liu, Yu 2
刊名	NEUROSCIENCE BULLETIN
	2022-11-08
页码	14
关键词	Virtual reality Spatial context Contextual behavior Hippocampus Place cell Learning and memory Ca2+ imaging
ISSN号	1673-7067
DOI	10.1007/s12264-022-00964-0
通讯作者	He, Hua(hehua1624@smmu.edu.cn) ; Liu, Yu(yu.liu@ia.ac.cn) ; Xu, Chun(chun.xu@ion.ac.cn)
英文摘要	Animal survival necessitates adaptive behaviors in volatile environmental contexts. Virtual reality (VR) technology is instrumental to study the neural mechanisms underlying behaviors modulated by environmental context by simulating the real world with maximized control of contextual elements. Yet current VR tools for rodents have limited flexibility and performance (e.g., frame rate) for context-dependent cognitive research. Here, we describe a high-performance VR platform with which to study contextual behaviors immersed in editable virtual contexts. This platform was assembled from modular hardware and custom-written software with flexibility and upgradability. Using this platform, we trained mice to perform context-dependent cognitive tasks with rules ranging from discrimination to delayed-sample-to-match while recording from thousands of hippocampal place cells. By precise manipulations of context elements, we found that the context recognition was intact with partial context elements, but impaired by exchanges of context elements. Collectively, our work establishes a configurable VR platform with which to investigate context-dependent cognition with large-scale neural recording.
资助项目	National Science and Technology Innovation[2022ZD0205000] ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32010105] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDBS01010100] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] ; National Natural Science Foundation of China[31771180] ; National Natural Science Foundation of China[91732106] ; International Collaborative Project of the Shanghai Science and Technology Committee[201978677] ; Lingang Lab[LG202104-01-08]
WOS关键词	HIPPOCAMPAL PLACE CELLS ; NEUROSCIENCE ; CIRCUITS
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000880355400001
资助机构	National Science and Technology Innovation ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Shanghai Municipal Science and Technology Major Project ; National Natural Science Foundation of China ; International Collaborative Project of the Shanghai Science and Technology Committee ; Lingang Lab
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/50705]
专题	综合信息系统研究中心_脑机融合与认知评估
通讯作者	He, Hua; Liu, Yu; Xu, Chun
作者单位	1.Navy Mil Med Univ, Dept Neurosurg, Affiliated Hosp 3, Shanghai 200438, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 3.Shanghai Ctr Brain Sci & Brain Inspired Intellige, Shanghai 201210, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Qu, Xue-Tong,Wu, Jin-Ni,Wen, Yunqing,et al. A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents[J]. NEUROSCIENCE BULLETIN,2022:14.
APA	Qu, Xue-Tong.,Wu, Jin-Ni.,Wen, Yunqing.,Chen, Long.,Lv, Shi-Lei.,...&Xu, Chun.(2022).A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents.NEUROSCIENCE BULLETIN,14.
MLA	Qu, Xue-Tong,et al."A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents".NEUROSCIENCE BULLETIN (2022):14.