Using Gradient Magnetic Fields to Control the Size and Uniformity of Iron Oxide Nanoparticles for Magnetic Resonance Imaging

doi:10.1021/acsanm.2c01392

	Using Gradient Magnetic Fields to Control the Size and Uniformity of Iron Oxide Nanoparticles for Magnetic Resonance Imaging
	Ma, Kun 5; Wang, Ze 4,5; Tao, Tongxiang 4,5; Xu, Shuai 4,5; Rehman, Sajid Ur 5; Yan, Xu 3; Fang, Jun 5; Chen, Ruiguo 5; Wang, Hui 5; Zhang, Xin 5
刊名	ACS APPLIED NANO MATERIALS
	2022-05-27
卷号	5
关键词	magnetic field strength magnetic field gradient magnetic nanoparticles reverse micelle T-1 contrast agent
DOI	10.1021/acsanm.2c01392
通讯作者	Lu, Yang(yanglu@hfut.edu.cn) ; Lu, Qingyou(qxl@ustc.edu.cn) ; Wang, Junfeng(junfeng@hmfl.ac.cn)
英文摘要	The size and uniformity of magnetic nanoparticles are essential for biomedical performance. In this study, we successfully controlled the size and uniformity of magnetic nanomaterials by applying gradient magnetic fields during the solvothermal method. This regulation method conforms to the following laws: the size of the synthesized magnetic nanoparticles (MNPs) is smaller when the applied magnetic field is stronger, and the synthesized uniformity is better when the product of the applied field and its gradient is greater. In vitro and in vivo magnetic resonance imaging experiments show that magnetic field treatment resulted in uniform MNPs of 4.5 nm, which can significantly improve the T-1 contrast performance. We further propose a dynamic process of field-induced reconfiguration for reverse micelles (re-micelles) to analyze how the gradient magnetic field affects MNP synthesis.
资助项目	National Natural Science Foundation of China[3190110313] ; National Natural Science Foundation of China[51627901] ; National Natural Science Foundation of China[U1932216] ; National Natural Science Foundation of China[U1632274] ; Ministry of Science and Technology o f China[2016YFA0400901] ; Ministry of Science and Technology o f China[2017YFA0402903] ; Alliance of International Science Organizations[ANSO-VF-2021-03] ; Hefei Science Center CAS[2020HSC-UE014]
WOS关键词	LARGE-SCALE SYNTHESIS ; REVERSE MICELLES ; NANOMATERIALS ; FUNCTIONALIZATION ; GROWTH ; AGENTS
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000833967000141
资助机构	National Natural Science Foundation of China ; Ministry of Science and Technology o f China ; Alliance of International Science Organizations ; Hefei Science Center CAS
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/132181]
专题	中国科学院合肥物质科学研究院
通讯作者	Lu, Yang; Lu, Qingyou; Wang, Junfeng
作者单位	1.Anhui Univ, Inst Informat Technol, Hefei 230601, Anhui, Peoples R China 2.Anhui Univ, Inst Phys Sci, Hefei 230601, Anhui, Peoples R China 3.Hefei Univ Technol, Sch Chem & Chem Engn, Hefei 230009, Anhui, Peoples R China 4.Univ Sci & Technol China, Hefei 230036, Anhui, Peoples R China 5.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Ma, Kun,Wang, Ze,Tao, Tongxiang,et al. Using Gradient Magnetic Fields to Control the Size and Uniformity of Iron Oxide Nanoparticles for Magnetic Resonance Imaging[J]. ACS APPLIED NANO MATERIALS,2022,5.
APA	Ma, Kun.,Wang, Ze.,Tao, Tongxiang.,Xu, Shuai.,Rehman, Sajid Ur.,...&Wang, Junfeng.(2022).Using Gradient Magnetic Fields to Control the Size and Uniformity of Iron Oxide Nanoparticles for Magnetic Resonance Imaging.ACS APPLIED NANO MATERIALS,5.
MLA	Ma, Kun,et al."Using Gradient Magnetic Fields to Control the Size and Uniformity of Iron Oxide Nanoparticles for Magnetic Resonance Imaging".ACS APPLIED NANO MATERIALS 5(2022).