Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ Cartilage Regeneration

doi:10.3389/fbioe.2022.940735

	Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ Cartilage Regeneration
	Zhang, Hanyuan 5,6,7; Fang, Weijun 4; Zhao, Tingting 4; Zhang, Huabing 4; Gao, Liang 2,3; Li, Jingya 6,7; Wang, Rujing 7; Xu, Weiping 1,6,7
刊名	FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
	2022-07-22
卷号	10
关键词	kartogenin cartilage regeneration dopamine magnetic resonance imaging (MRI) hydrogels
ISSN号	2296-4185
DOI	10.3389/fbioe.2022.940735
通讯作者	Xu, Weiping(weipingx@ustc.edu.cn)
英文摘要	The cartilage has poor ability to mount a sufficient healing response. Herein, kartogenin (KGN), an emerging stable non-protein compound with the ability to recruit bone marrow mesenchyme stem cells (BMSCs) to promote chondrogenic differentiation, was grafted onto dopamine-Fe(III) chelating nanoparticles, followed by involving a gelatin- and dextran-based injectable hydrogel to mimic the extracellular matrix to promote cartilage repair. The in vitro results demonstrated that KGN underwent long-term sustained release behavior and availably promoted the deep migration of BMSC cells in yielding hydrogels. Furthermore, in vivo New Zealand white rabbits' cartilage defect model repairing results showed that cartilage defect obtained significant regeneration post operation in the 12th week, and the defect edge almost disappeared compared to adjacent normal cartilage tissue. Meanwhile, the T-2-weighted magnetic resonance imaging (MRI) property resulting from dissociative Fe (III) can significantly monitor the degradation degree of the implanted hydrogels in the defect site. This integrated diagnosis and treatment system gives insight into cartilage regeneration.
资助项目	National Natural Science Foundation of China[52072360] ; National Natural Science Foundation of China[51672004] ; Key Research and Development Program of Anhui Province (China)[1804h08020252] ; Natural Science Foundation of Anhui Province (China)[1608085MH176] ; Natural Science Foundation of Anhui Province (China)[1908085QB65]
WOS关键词	HYALURONIC-ACID ; SCAFFOLDS ; COLLAGEN ; GELATIN ; REPAIR
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000837103200001
资助机构	National Natural Science Foundation of China ; Key Research and Development Program of Anhui Province (China) ; Natural Science Foundation of Anhui Province (China)
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/132161]
专题	中国科学院合肥物质科学研究院
通讯作者	Xu, Weiping
作者单位	1.Univ Sci & Technol China, Affiliated Hosp 1, Div Life Sci & Med, USTC, Hefei, Peoples R China 2.Sino Euro Orthopaed Network, Berlin, Germany 3.Hua Tuo Inst Med Innovat HTIMI, Wuhan, Peoples R China 4.Anhui Med Univ, Sch Basic Med Sci, Hefei, Peoples R China 5.Anhui Med Univ, Dept Orthoped, Affiliated Hosp 1, Hefei, Peoples R China 6.Univ Sci & Technol China, Dept Biol Phys, Hefei, Peoples R China 7.Chinese Acad Sci, Inst Intelligent Machines, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hanyuan,Fang, Weijun,Zhao, Tingting,et al. Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ Cartilage Regeneration[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2022,10.
APA	Zhang, Hanyuan.,Fang, Weijun.,Zhao, Tingting.,Zhang, Huabing.,Gao, Liang.,...&Xu, Weiping.(2022).Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ Cartilage Regeneration.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,10.
MLA	Zhang, Hanyuan,et al."Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ Cartilage Regeneration".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10(2022).