In Situ Upregulating Heat Shock Protein 70 via Gastric Nano-Heaters for the Interference of Helicobacter pylori Infection

doi:10.1021/acsnano.2c03911

	In Situ Upregulating Heat Shock Protein 70 via Gastric Nano-Heaters for the Interference of Helicobacter pylori Infection
	Xia, Xin 2; Yin, Zhiwei 2; Yang, Yanxia 2; Li, Shengkai 2; Wang, Linlin 2; Cai, Xinqi 2; Xu, Yiting 3; Ma, Chao 4; Qiu, Ye 2; Chen, Zhuo 2
刊名	ACS NANO
	2022-08-22
关键词	Helicobacter pylori infection antibacterial therapy magnetothermal stimulation protein regulation gastric nano-heaters
ISSN号	1936-0851
DOI	10.1021/acsnano.2c03911
通讯作者	Chen, Zhuo(zhuochen@hnu.edu.cn)
英文摘要	Taking inspiration from the mechanism of Helicobacter pylori infection can lead to innovative antibacterial ways to fight antibiotics resistance. Herein, a gastric nano-heater iron- cobalt alloy shielded with graphitic shells (FeCo@G) is developed to interfere with H. pylori infection under an alternating magnetic field. FeCo@G shows a high and stable specific loss power (SLP = 534.1 W g(-1)) in the acidic environment and provides efficient magnetothermal stimulation in the stomach. Such stimulation upregulates the cytoprotective heat shock protein 70 (HSP70) in gastric epithelial cells, which antagonizes the infection of H. pylori. This finding is further supported by the transcriptomic analysis verifying the upregulation of HSP70 in the stomach. Moreover, the nanoheater shows a high inhibition rate of H. pylori in vivo with good biocompatibility; 95% of FeCo@G is excreted from the mouse's gastrointestinal tract within 12 h. In summary, FeCo@G allows magnetothermal therapy to be used in harsh gastric environments, providing an approach for the therapy against H. pylori.
资助项目	National Key Research and Development Program of China[2020YFA0210800] ; National Natural Science Foundation of China[21522501] ; National Natural Science Foundation of China[22225401] ; Science and Technology Innovation Program of Hunan Province[2020RC4017]
WOS关键词	SHOCK PROTEINS ; PYLORI ; EXPRESSION ; HSP70 ; NANOPARTICLES ; ACTIVATION ; GROWTH ; BRAIN ; ACID
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000848459400001
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Science and Technology Innovation Program of Hunan Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131844]
专题	中国科学院合肥物质科学研究院
通讯作者	Chen, Zhuo
作者单位	1.Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med IMM, Sch Med, Shanghai 200240, Peoples R China 2.Hunan Univ, Coll Chem & Chem Engn, Coll Biol, Aptamer Engn Ctr Hunan Prov,State Key Lab Chemo Bi, Changsha 410082, Hunan, Peoples R China 3.Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ, Xiangtan 411201, Hunan, Peoples R China 4.Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Hunan, Peoples R China 5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC, Chinese Acad Sci,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 6.Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Xia, Xin,Yin, Zhiwei,Yang, Yanxia,et al. In Situ Upregulating Heat Shock Protein 70 via Gastric Nano-Heaters for the Interference of Helicobacter pylori Infection[J]. ACS NANO,2022.
APA	Xia, Xin.,Yin, Zhiwei.,Yang, Yanxia.,Li, Shengkai.,Wang, Linlin.,...&Tan, Weihong.(2022).In Situ Upregulating Heat Shock Protein 70 via Gastric Nano-Heaters for the Interference of Helicobacter pylori Infection.ACS NANO.
MLA	Xia, Xin,et al."In Situ Upregulating Heat Shock Protein 70 via Gastric Nano-Heaters for the Interference of Helicobacter pylori Infection".ACS NANO (2022).