Differential diagnosis of non-diffuse primary thyroid lymphoma and papillary thyroid carcinoma by ultrasound combined with computed tomography

doi:10.1186/s12885-022-10035-2

	Differential diagnosis of non-diffuse primary thyroid lymphoma and papillary thyroid carcinoma by ultrasound combined with computed tomography
	Peng, Chanjuan 2,3; Yi, Dan 1; Zhou, Ying 4; Yao, Jincao 2,3; Chen, Bo 5; Yang, Chen 2,3; Xu, Dong 2,3,6,7
刊名	BMC CANCER
	2022-08-31
卷号	22
关键词	Sonography CT Primary thyroid lymphoma Papillary thyroid carcinoma
DOI	10.1186/s12885-022-10035-2
通讯作者	Yang, Chen(yangchen@zjcc.org.cn) ; Xu, Dong(xudong@zjcc.org.cn)
英文摘要	Background: Primary thyroid lymphoma (PTL) and papillary thyroid carcinoma (PTC) are both thyroid malignancies, but their therapeutic methods and prognosis are different. This study aims to explore their sonographic and computed tomography(CT)features, and to improve the early diagnosis rate. Methods: The clinical and imaging data of 50 patients with non-diffuse PTL and 100 patients with PTC confirmed by pathology were retrospectively analysed. Results: Of the 150 patients, from the perspective of clinical data, between non-diffuse PTL and PTC patients existed significant difference in age, maximum diameter of nodule, asymmetric enlargement and Hashimoto's thyroiditis (P < 0.001), but not in gender ratio, echo texture, cystic change and anteroposterior-to-transverse ratio (P > 0.05). With respect to sonographic feature, non-diffuse PTL patients had a higher proportion than PTC patients in markedly hypoechoic, internal linear echogenic strands, posterior echo enhancement, rich vascularity, lack of calcification and homogeneous enhancement, with statistically significant difference (P < 0.05), while PTC patients had a higher proportion than non-diffuse PTL patients in irregular border, circumscribed margin, capsular invasion and significant enhancement, with statistically significant difference (P < 0.001). With respect to CT feature, non-diffuse PTL patients were significantly different from PTC patients in the non-contrast CT value mean, venous phase CT value mean, enhanced intensity and homogeneity of nodules (P < 0.05). Multivariate logistic regression analysis showed that age (OR = 1.226, 95%CI:1.056 similar to 1.423, P = 0.007), posterior echo enhancement (OR = 51.152, 95%CI: 2.934 similar to 891.738, P = 0.007), lack of calcification (OR = 0.013, 95%CI: 0.000 similar to 0.400, P = 0.013) and homogeneous enhancement (OR = 0.020, 95%CI: 0.001 similar to 0.507, P = 0.018) were independent risk factors. Conclusions: Sonographic and CT features of the presence of posterior echo enhancement, lack of calcification and homogeneous enhancement were valuable to distinguishing non-diffuse PTL from PTC.
资助项目	Zhejiang Province Public Welfare Technology Application Research Project[LGC22H180004] ; National Natural Science Foundation of China[82071946] ; Zhejiang Provincial Natural Science Foundation[LZY21F030001] ; Zhejiang Provincial Natural Science Foundation[LSD19H180001]
WOS关键词	HASHIMOTO THYROIDITIS ; ULTRASONOGRAPHY ; FEATURES ; NODULES ; CANCER
WOS研究方向	Oncology
语种	英语
出版者	BMC
WOS记录号	WOS:000847676800001
资助机构	Zhejiang Province Public Welfare Technology Application Research Project ; National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131826]
专题	中国科学院合肥物质科学研究院
通讯作者	Yang, Chen; Xu, Dong
作者单位	1.Shaoxing Peoples Hosp, Dept Ultrasound, Hangzhou 312000, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Ultrasound, 1 East Banshan 7 Rd, Hangzhou 310022, Peoples R China 3.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Peoples R China 4.Hebei Prov Hosp Tradit Chinese Med, Dept Surg, Shijiazhuang 050000, Hebei, Peoples R China 5.Shaoxing Peoples Hosp, Dept Radiol, Shaoxing 312000, Peoples R China 6.Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou 310022, Peoples R China 7.Zhejiang Prov Res Ctr Canc Intelligent Diag & Mol, Hangzhou 310022, Peoples R China
推荐引用方式 GB/T 7714	Peng, Chanjuan,Yi, Dan,Zhou, Ying,et al. Differential diagnosis of non-diffuse primary thyroid lymphoma and papillary thyroid carcinoma by ultrasound combined with computed tomography[J]. BMC CANCER,2022,22.
APA	Peng, Chanjuan.,Yi, Dan.,Zhou, Ying.,Yao, Jincao.,Chen, Bo.,...&Xu, Dong.(2022).Differential diagnosis of non-diffuse primary thyroid lymphoma and papillary thyroid carcinoma by ultrasound combined with computed tomography.BMC CANCER,22.
MLA	Peng, Chanjuan,et al."Differential diagnosis of non-diffuse primary thyroid lymphoma and papillary thyroid carcinoma by ultrasound combined with computed tomography".BMC CANCER 22(2022).