Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021

doi:10.3389/fnut.2022.1060436

	Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021
	Li, Rongrong 1; Huang, Qingcheng 2; Ye, Chenxiao 2; Wu, Changhong 3; Luo, Ning 4; Lu, Yi 5; Fang, Jianqiao 1; Wang, Yun 6
刊名	FRONTIERS IN NUTRITION
	2022-11-10
卷号	9
关键词	bibliometric analysis ketogenic diet cancer mechanism immunotherapy clinical trials
ISSN号	2296-861X
DOI	10.3389/fnut.2022.1060436
通讯作者	Lu, Yi(luyi@zjcc.org.cn) ; Fang, Jianqiao(fangjianqiao7532@163.com) ; Wang, Yun(wangyun61689756@163.com)
英文摘要	Increasing evidence demonstrated that the ketogenic diet (KD) played a positive effect on cancer treatment. However, no systematic review and bibliometric analysis were conducted in this field. This study aimed to explore the current status, and reveal the potential trends and hotspots to provide a reference for future research. Publications were extracted from the Web of Science Core Collection. CiteSpace (5.6.R3) software and the website of bibliometrics were used for visual analysis. A total of 500 publications with 334 articles and 166 reviews were included, with the timespan of 2012 to 2021. The United States was the most productive country. Majority of the top 10 institutions were from the United States, and Harvard University was the top-contributing institution. The most prolific author and the co-cited author was Thomas N Seyfried from Boston College. The highest cited reference was published in PLoS ONE, authored by Abdelwahab Mohammed G, with 161 citations. Glioma and breast cancer were the most common types of cancer in this field, while hepatocellular carcinoma and pancreatic cancer were the new hotspots. The anti-tumor mechanism of KD mainly focused on regulating metabolism, decanoic acid, oxidative stress, fatty acid oxidation, and cell apoptosis. Additionally, the presence of "chemotherapy" and "radiotherapy" in the keywords indicated that KD combined with anti-tumor research was a topic, while "immunotherapy" has became a recent frontiers. Notably, as a metabolic therapy, KD was deserved more attention in the treatment of hepatocellular carcinoma and pancreatic cancer, and KD combined with immunotherapy was the new hotspot and frontier. Additionally, more molecular studies and high-quality uniformly, randomized, controlled clinical trials are urgently warranted to evaluate the effect of KD in multiple cancers.
资助项目	Traditional Chinese Medicine Research Program of Zhejiang Province ; Medical and Health Platform Program of Zhejiang Province ; [2018ZQ020] ; [2021KY556]
WOS关键词	METABOLICALLY SUPPORTED CHEMOTHERAPY ; HYPERBARIC-OXYGEN THERAPY ; LUNG-CANCER ; HYPERTHERMIA
WOS研究方向	Nutrition & Dietetics
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000889355200001
资助机构	Traditional Chinese Medicine Research Program of Zhejiang Province ; Medical and Health Platform Program of Zhejiang Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131624]
专题	中国科学院合肥物质科学研究院
通讯作者	Lu, Yi; Fang, Jianqiao; Wang, Yun
作者单位	1.Zhejiang Chinese Med Univ, Affiliated Hosp 3, Hangzhou, Peoples R China 2.Zhejiang Chinese Med Univ, Clin Coll 1, Hangzhou, Peoples R China 3.Zhejiang Chinese Med Univ, Clin Coll 2, Hangzhou, Peoples R China 4.Zhejiang Chinese Med Univ, Clin Coll 3, Hangzhou, Peoples R China 5.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Inst Basic Med & Canc,Dept Clin Nutr, Hangzhou, Peoples R China 6.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Oncol, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Li, Rongrong,Huang, Qingcheng,Ye, Chenxiao,et al. Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021[J]. FRONTIERS IN NUTRITION,2022,9.
APA	Li, Rongrong.,Huang, Qingcheng.,Ye, Chenxiao.,Wu, Changhong.,Luo, Ning.,...&Wang, Yun.(2022).Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021.FRONTIERS IN NUTRITION,9.
MLA	Li, Rongrong,et al."Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021".FRONTIERS IN NUTRITION 9(2022).