Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey

doi:10.21037/atm-22-991

	Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey
	Yu, Yan-Qin 1,2; Ma, Li 3; Wang, Wen-Jun 4; Zhao, Yu-Qian 5; Xu, Hui-Fang 6; Cao, Ji 7,8; Li, Li 9; Hao, Jin-Qi 2; Gao, Jing-Ru 2; Gu, Xiao-Fen 10
刊名	ANNALS OF TRANSLATIONAL MEDICINE
	2022-03-01
卷号	10
关键词	Health-related quality of life (HRQOL) colorectal cancer (CRC) China
ISSN号	2305-5839
DOI	10.21037/atm-22-991
通讯作者	Zhang, Xi(zhangxipkuch@163.com) ; Zhang, Shao-Kai(shaokaizhang@126.com) ; Qiao, You-Lin(qiaoy@cicams.ac.cn)
英文摘要	Background: Colorectal cancer (CRC) is one of the most common cancers in China, and most CRC patients have already reached an advanced stage by the time of initial diagnosis. Due to the loss of health as a result of cancer, it has consequence on the treatment which may affect the psychophysical and social impairment of CRC patients. These indicators (psychophysical, function and social impairment) affect the health-related quality of life (HRQOL). There are limited studies that focus on advanced CRC patients in China. This study aimed to assess the HRQOL and its associated factors of advanced CRC patients in China. Methods: This was a cross-sectional, nationwide, hospital-based, and multi-center survey. According to the traditional administrative district definition, we selected 19 hospitals in 7 regions by multi-stage stratified sampling in China. For each eligible CRC patient with stage III or IV in the selected hospitals, socio-demographics, clinical information, and HRQOL were collected based on patients' self-reporting and/or medical records between March 2020 and March 2021. Patients completed the Functional Assessment of Cancer Therapy Colorectal (FACT-C) plus-traditional Chinese version of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-9. Results: A total of 4,589 CRC patients (mean age 60.1 years, including 2,730 males and 1,859 females) were included. The total score of HRQOL in population was 128.2 +/- 24.70. There were significant differences in the overall score of HRQOL in gender, education level, occupation, region, disease type, and disease stage (P<0.05). The score of HRQOL was better in males, undergraduates and above, unemployed/ laid-off, and southwestern and central China. Multivariate analysis showed that education level, occupation, location, number of hospitals visited and treatment methods, and gender were associated with utilities of CRC patients. Conclusions: The HRQOL is an important outcome measure for CRC patients. The HRQOL scores differed according to socio-demographic and clinical characteristics, and findings of these factors were associated with education level, occupation, region, number of visited and treatment methods, and gender.
资助项目	Beijing Love Book Cancer Foundation ; Merck Serono Co. Ltd.
WOS关键词	MORTALITY ; SURVIVORS ; CHEMOTHERAPY ; PREDICTORS
WOS研究方向	Oncology ; Research & Experimental Medicine
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000785814200081
资助机构	Beijing Love Book Cancer Foundation ; Merck Serono Co. Ltd.
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131523]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Xi; Zhang, Shao-Kai; Qiao, You-Lin
作者单位	1.Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Dept Canc Epidemiol,Natl Canc Ctr, Beijing, Peoples R China 2.Baotou Med Coll, Clin Epidmiol Res Ctr, Dept Publ Hlth & Prevent Med, Baotou, Peoples R China 3.Dalian Med Univ, Publ Hlth Sch, Dalian, Peoples R China 4.Jining Med Univ, Sch Nursing, Jining, Peoples R China 5.Univ Elect Sci & Technol China, Sichuan Canc Ctr, Sch Med, Sichuan Canc Hosp & Inst, Chengdu, Peoples R China 6.Zhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control, Dept Canc Epidmiol,Affiliated Canc Hosp,Henan Int, 127 Dongming Rd, Zhengzhou 450008, Peoples R China 7.Guangxi Med Univ, Affiliated Hosp 1, Dept Canc Prevent, Nanning, Peoples R China 8.Guangxi Med Univ, Affiliated Hosp 1, Control Off, Nanning, Peoples R China 9.Jinan Univ, Affiliated Hosp 1, Dept Clin Res, Guangzhou, Peoples R China 10.Xinjiang Med Univ, Affiliated Tumor Hosp, Dept Student Affairs, Urumqi, Peoples R China
推荐引用方式 GB/T 7714	Yu, Yan-Qin,Ma, Li,Wang, Wen-Jun,et al. Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey[J]. ANNALS OF TRANSLATIONAL MEDICINE,2022,10.
APA	Yu, Yan-Qin.,Ma, Li.,Wang, Wen-Jun.,Zhao, Yu-Qian.,Xu, Hui-Fang.,...&Qiao, You-Lin.(2022).Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey.ANNALS OF TRANSLATIONAL MEDICINE,10.
MLA	Yu, Yan-Qin,et al."Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey".ANNALS OF TRANSLATIONAL MEDICINE 10(2022).