Engineering CpG-ASO-Pt-Loaded Macrophages (CAP@M) For Synergistic Chemo-/Gene-/Immuno-Therapy

doi:10.1002/adhm.202201178

	Engineering CpG-ASO-Pt-Loaded Macrophages (CAP@M) For Synergistic Chemo-/Gene-/Immuno-Therapy
	Wang, Yuqi 2,3; Zhang, Lingpu 1; Liu, Yan 3; Tang, Linlin 3; He, Juan 4; Sun, Xiaqing 2,3; Younis, Muhsin H.5,6; Cui, Daxiang 3; Xiao, Haihua 1; Gao, Dong 4
刊名	ADVANCED HEALTHCARE MATERIALS
	2022-06-19
关键词	cell therapy DNA nanobiotechnology drug delivery macrophages synergistic therapy
ISSN号	2192-2640
DOI	10.1002/adhm.202201178
通讯作者	Gao, Dong(dong.gao@sibcb.ac.cn) ; Kong, Xiang-Yang(xykong@sjtu.edu.cn) ; Cai, Weibo(wcai@uwhealth.org) ; Song, Jie(sjie@sjtu.edu.cn)
英文摘要	Adoptive cell therapy by natural cells for drug delivery has achieved encouraging progress in cancer treatment over small-molecule drugs. Macrophages have a great potential in antitumor drug delivery due to their innate capability of sensing chemotactic cues and homing toward tumors. However, major challenge in current macrophage-based cell therapy is loading macrophages with adequate amounts of therapeutic, while allowing them to play a role in immunity without compromising cell functions. Herein, a potent strategy to construct a macrophage-mediated drug delivery platform loaded with a nanosphere (CpG-ASO-Pt) (CAP) composed of functional nucleic acid therapeutic (CpG-ASO) and chemotherapeutic drug cisplatin (Pt) is demonstrated. These CAP nanosphere loaded macrophages (CAP@M) are employed not only as carriers to deliver this nanosphere toward the tumor sites, but also simultaneously to guide the differentiation and maintain immunostimulatory effects. Both in vitro and in vivo experiments indicate that CAP@M is a promising nanomedicine by macrophage-mediated nanospheres delivery and synergistically immunostimulatory activities. Taken together, this study provides a new strategy to construct a macrophage-based drug delivery system for synergistic chemo-/gene-/immuno-therapy.
资助项目	National Natural Science Foundation of China[81822024] ; National Natural Science Foundation of China[22161132008] ; Natural Science Foundation of Shanghai[19520714100] ; Natural Science Foundation of Shanghai[19ZR1475800] ; Project of Shanghai Jiao Tong University[2019QYA03] ; Project of Shanghai Jiao Tong University[YG2017ZD07] ; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, University of Wisconsin - Madison ; National Institutes of Health[P30CA014520] ; Lloyd's Register Foundation[ICON-2017-24]
WOS关键词	CANCER ; DELIVERY ; FACILE ; EFFLUX ; CARS
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000812698900001
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Shanghai ; Project of Shanghai Jiao Tong University ; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, University of Wisconsin - Madison ; National Institutes of Health ; Lloyd's Register Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131343]
专题	中国科学院合肥物质科学研究院
通讯作者	Gao, Dong; Kong, Xiang-Yang; Cai, Weibo; Song, Jie
作者单位	1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Elect Informat & Elect Engn, Dept Instrument Sci & Engn, Inst Nano Biomed & Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China 4.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol,State Key Lab C, CAS Ctr Excellence Mol Cell Sci,Shanghai Key Lab, Shanghai 200031, Peoples R China 5.Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA 6.Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA 7.Univ Chinese Acad Sci, Chinese Acad Sci, Canc Hosp, Inst Canc & Basic Med IBMC, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yuqi,Zhang, Lingpu,Liu, Yan,et al. Engineering CpG-ASO-Pt-Loaded Macrophages (CAP@M) For Synergistic Chemo-/Gene-/Immuno-Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2022.
APA	Wang, Yuqi.,Zhang, Lingpu.,Liu, Yan.,Tang, Linlin.,He, Juan.,...&Song, Jie.(2022).Engineering CpG-ASO-Pt-Loaded Macrophages (CAP@M) For Synergistic Chemo-/Gene-/Immuno-Therapy.ADVANCED HEALTHCARE MATERIALS.
MLA	Wang, Yuqi,et al."Engineering CpG-ASO-Pt-Loaded Macrophages (CAP@M) For Synergistic Chemo-/Gene-/Immuno-Therapy".ADVANCED HEALTHCARE MATERIALS (2022).