Pulmonary Salivary Gland Tumor, Mucoepidermoid Carcinoma: A Literature Review

doi:10.1155/2022/9742091

	Pulmonary Salivary Gland Tumor, Mucoepidermoid Carcinoma: A Literature Review
	Hu, Shumin 1,2,3,4; Gong, Jiali 1,2,3,4; Zhu, Xiu 4,5; Lu, Hongyang 1,2,3,4
刊名	JOURNAL OF ONCOLOGY
	2022-11-02
卷号	2022
ISSN号	1687-8450
DOI	10.1155/2022/9742091
通讯作者	Lu, Hongyang(luhy@zjcc.org.cn)
英文摘要	Pulmonary mucoepidermoid carcinoma (PMEC) is the most common malignant salivary gland tumor in the lungs and accounts for 0.1-0.2% of all lung malignancies in adults. It has no specific epidemiological or clinical characteristics. Correct diagnosis requires the combined examinations of images, laboratories, pathology, and immunohistochemistry (IHC) as well as molecular characteristics. PMEC tumors are characterized by squamous, intermediate, and mucus-secreting cells. Currently, histological appearance, mitotic frequency, cellular atypia, and necrocytosis allow the classification of PMEC into low grade or high grade. Molecular changes are crucial to pathological diagnosis. The driver of PMEC seems to be the fusion protein MECT1-MAML2 that is generated from a genetic mutation in t (11; 19) (q21; p13), while other gene mutations are also reported. However, no treatment of PMEC exists so far; surgical excision is still the primary treatment, while the efficacies of chemotherapy or radiotherapy are undefined. Tyrosine kinase inhibitor (TKI) therapy and immunotherapy showed to have significant therapeutic effects but require more investigation and better understanding. This review focuses on the clinical characteristics, imaging and pathologic features, immunohistochemical examination, mutation analysis, differential diagnosis, prognosis, and treatment of PMEC.
资助项目	Wu Jieping Medical Foundation ; [320.6750.2021-01-50]
WOS关键词	PROGRAMMED DEATH LIGAND-1 ; GROWTH-FACTOR RECEPTOR ; DIFFERENTIAL-DIAGNOSIS ; CELL CARCINOMA ; FREE SURVIVAL ; LUNG-CANCER ; FEATURES ; EGFR ; EXPRESSION ; OUTCOMES
WOS研究方向	Oncology
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000885044500003
资助机构	Wu Jieping Medical Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/130423]
专题	中国科学院合肥物质科学研究院
通讯作者	Lu, Hongyang
作者单位	1.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou 310053, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Zhejiang Key Lab Diag & Treatment Technol Torac On, Canc Hosp, Hangzhou 310022, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Torac Med Oncol, Zhejiang 310022, Peoples R China 4.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Beijing 310022, Peoples R China 5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Pathol, Zhejiang 310022, Peoples R China
推荐引用方式 GB/T 7714	Hu, Shumin,Gong, Jiali,Zhu, Xiu,et al. Pulmonary Salivary Gland Tumor, Mucoepidermoid Carcinoma: A Literature Review[J]. JOURNAL OF ONCOLOGY,2022,2022.
APA	Hu, Shumin,Gong, Jiali,Zhu, Xiu,&Lu, Hongyang.(2022).Pulmonary Salivary Gland Tumor, Mucoepidermoid Carcinoma: A Literature Review.JOURNAL OF ONCOLOGY,2022.
MLA	Hu, Shumin,et al."Pulmonary Salivary Gland Tumor, Mucoepidermoid Carcinoma: A Literature Review".JOURNAL OF ONCOLOGY 2022(2022).