RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation

doi:10.1016/j.bbrc.2022.05.076

	RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation
	Hao, Wei-Yuan 4; Lou, Yan 2; Hu, Guo-Ying 5; Qian, Chao-Yi 4; Liang, Wei-Ren 4; Zhao, Jun 1; Wang, Xiao-Hong 3
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2022-08-06
卷号	616
关键词	YTHDF1 N-6-methyladenosine Inflammation NLRP3
ISSN号	0006-291X
DOI	10.1016/j.bbrc.2022.05.076
通讯作者	Zhao, Jun(zhaojun_hangzhou@sina.com) ; Wang, Xiao-Hong(xhwang2022@sina.com)
英文摘要	N6-methyladenosine (m6A) modification of mRNAs is involved in multiple essential biological processes, dynamically regulated by m6A "writers", "erasers", and "readers". Yet, the detailed functional roles of RNA m6A reader proteins, such as YTHDFs, are largely unknown. Herein we show that YTHDF1 promotes pro-inflammatory IL-1 beta production in macrophages during bacterial infections. YTHDF1 overexpression promotes NLRP3 translation. In vivo knockdown of YTHDF1 facilitates survival in a mouse model of sepsis. Thus, YTHDF1 participates in inflammatory responses and subsequent injuries, serving as a new potential therapeutic target in clinical treatment of inflammatory diseases. (C) 2022 Published by Elsevier Inc.
资助项目	Zhejiang Medical Health Science and Technology Program[2021KY561] ; Zhejiang Medical Health Science and Technology Program[2022KY662]
WOS关键词	NUCLEAR-RNA
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000880287000012
资助机构	Zhejiang Medical Health Science and Technology Program
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/130345]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhao, Jun; Wang, Xiao-Hong
作者单位	1.Zhejiang Med & Hlth Grp Hangzhou Hosp, Dept Respirat & Crit Care Med, Zhejiang Canc Hosp, Cooperat Hosp, 1 Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China 2.Zhejiang Med & Hlth Grp Hangzhou Hosp, Dept Intens Care Unit, Zhejiang Canc Hosp, Cooperat Hosp, 1 Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China 3.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Canc & Basic Med ICBM, Dept Intestinal Oncol,Canc Hosp,Zhejiang Canc Hos, 1 East Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China 4.Chinese Acad Sci, Univ Chinese Acad Sci, Dept InterventCanc Hosp, Zhejiang Canc Hosp,Inst Canc & Basic Med ICBM, 1 East Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China 5.Zhejiang Med & Hlth Grp Hangzhou Hosp, Dept Infect Dis, Zhejiang Canc Hosp, Cooperat Hosp, 1 Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Hao, Wei-Yuan,Lou, Yan,Hu, Guo-Ying,et al. RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2022,616.
APA	Hao, Wei-Yuan.,Lou, Yan.,Hu, Guo-Ying.,Qian, Chao-Yi.,Liang, Wei-Ren.,...&Wang, Xiao-Hong.(2022).RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,616.
MLA	Hao, Wei-Yuan,et al."RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 616(2022).