Olanzapine for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review to Identify the Best Way to Administer the Drug

doi:10.3390/curroncol29110650

	Olanzapine for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review to Identify the Best Way to Administer the Drug
	Zhang, Xiao-Ling 2; Ying, Jie-Er 1
刊名	CURRENT ONCOLOGY
	2022-11-01
卷号	29
关键词	olanzapine CINV mechanism dosage time routes
ISSN号	1198-0052
DOI	10.3390/curroncol29110650
通讯作者	Ying, Jie-Er(jieerying@aliyun.com)
英文摘要	Common treatment methods for malignant tumors include surgery, chemotherapy, radiotherapy, immunotherapy, targeted therapy, etc., among which chemotherapy plays an important role. However, chemotherapy brings corresponding side effects while killing tumor cells, and nausea and vomiting are the most common adverse reactions induced by chemotherapy. It not only affects the patient's appetite, resulting in malnutrition and electrolyte disturbances, but also reduces the patient's compliance with treatment, which further aggravates the disease. Thus, it is important to quickly prevent and cure nausea and vomiting induced by chemotherapy (CINV). In addition, with the continuous development of medicine, more and more antiemetic drugs have been developed. At present, the most common antiemetic agents for chemotherapy-induced nausea and vomiting are NK-1R antagonists, 5-HT3R antagonists, and dexamethasone. Surprisingly, olanzapine, often used as a psychotropic drug, has been found to be an effective antiemetic and is similar to other regimens on the safety of medicine. However, although there are numerous studies on the antiemetic effects of olanzapine, its comprehensive application remains unclear. Therefore, this review will elaborate the antiemetic effect of olanzapine in terms of the antiemetic mechanism and the safety, economic cost, dose, administration time, and drug delivery aspects.
WOS关键词	CISPLATIN-BASED CHEMOTHERAPY ; CINV STUDY-GROUP ; DOUBLE-BLIND ; INTRAMUSCULAR OLANZAPINE ; ANTIEMETIC THERAPY ; CANCER-PATIENTS ; PHASE-II ; 5 MG ; EFFICACY ; DEXAMETHASONE
WOS研究方向	Oncology
语种	英语
出版者	MDPI
WOS记录号	WOS:000881008000001
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/130335]
专题	中国科学院合肥物质科学研究院
通讯作者	Ying, Jie-Er
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 2.Wenzhou Med Univ, Wenzhou 325000, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xiao-Ling,Ying, Jie-Er. Olanzapine for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review to Identify the Best Way to Administer the Drug[J]. CURRENT ONCOLOGY,2022,29.
APA	Zhang, Xiao-Ling,&Ying, Jie-Er.(2022).Olanzapine for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review to Identify the Best Way to Administer the Drug.CURRENT ONCOLOGY,29.
MLA	Zhang, Xiao-Ling,et al."Olanzapine for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review to Identify the Best Way to Administer the Drug".CURRENT ONCOLOGY 29(2022).