The Effect of Long-Term Moderate Static Magnetic Field Exposure on Adult Female Mice

doi:10.3390/biology11111585

	The Effect of Long-Term Moderate Static Magnetic Field Exposure on Adult Female Mice
	Yang, Xingxing 2; Yu, Biao 1; Song, Chao 1; Feng, Chuanlin 1; Zhang, Jing 1; Wang, Xinyu 1; Cheng, Guofeng 1; Yang, Rui 2; Wang, Wei 2; Zhu, Yong 2
刊名	BIOLOGY-BASEL
	2022-11-01
卷号	11
关键词	static magnetic field long-term female behavioral antioxidant capacity
DOI	10.3390/biology11111585
通讯作者	Zhu, Yong(yzhu@hfnu.edu.cn)
英文摘要	Because of the high cost and safety of ultra-high magnetic resonance imaging (MRI), its application has certain limitations. Whereas 0.5-3 T MRI has been widely applied in hospitals, static magnetic fields (SMFs) have been shown to improve mice mental health and have anti-tumor potentials. Here, we compared the effects of the upward and downward 150 mT SMF groups with the sham group on C57BL/6J adult female mice. Locomotor and exploratory activity were also measured by behavioral tests, including the open field and elevated plus test. Additionally, physiology, pathology indicators and gut microbiota were examined. We found that 150 mT SMFs long-term exposure enhanced locomotive and exploratory activity of mice, especially the downward 150 mT SMF. Compared with the downward 150 mT SMF group, the movement speed and distance in the center area of the sham group were increased by 65.99% (p < 0.0001) and 68.58% (p = 0.0038), respectively. Moreover, compared to the sham group, downward 150 mT SMF increased the number of entrances to the center area by 67.0% (p = 0.0082) and time in the center area by 77.12% (p = 0.0054). Additionally, we observed that upward 150 mT SMF improved the number of follicles (similar to 2.5 times, p = 0.0325) and uterine glands through increasing the total antioxidant capacity and reducing lipid peroxidation level in mice. Gut microbiome analysis showed that 150 mT SMFs long-term exposure improved the microbiota abundance (Clostridium, Bifidobacterium, Ralstonia and Yaniella) in the genus level, which may affect metabolism, anxiety and behavior in adult female mice. Our results demonstrated that 150 mT SMFs long-term exposure not only had good biosafety, but also improved athletic performance, emotion and the function of ovarian, uterine and gut microbiota abundance in adult female mice, which unraveled the potential of moderate long-term SMF exposure in clinical applications.
资助项目	Anhui Provincial Natural Science Research Project of Higher Education[KJ2021A0925] ; Anhui Provincial Natural Science Research Project of Higher Education[KJ2020A0095] ; Anhui Provincial Natural Science Foundation[2008085MC105] ; Research Foundation for Talented Scholars of Hefei Normal University[2020rcjj46] ; Research Foundation for Talented Scholars of Hefei Normal University[2022rcjj21]
WOS关键词	LIPID-METABOLISM ; DOUBLE-BLIND ; GLUCOSE ; ANXIETY ; DEPRESSION ; HORMONES ; SEX
WOS研究方向	Life Sciences & Biomedicine - Other Topics
语种	英语
出版者	MDPI
WOS记录号	WOS:000881030400001
资助机构	Anhui Provincial Natural Science Research Project of Higher Education ; Anhui Provincial Natural Science Foundation ; Research Foundation for Talented Scholars of Hefei Normal University
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/130190]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhu, Yong
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Peoples R China 2.Hefei Normal Univ, Sch Life Sci, Hefei 230601, Peoples R China
推荐引用方式 GB/T 7714	Yang, Xingxing,Yu, Biao,Song, Chao,et al. The Effect of Long-Term Moderate Static Magnetic Field Exposure on Adult Female Mice[J]. BIOLOGY-BASEL,2022,11.
APA	Yang, Xingxing.,Yu, Biao.,Song, Chao.,Feng, Chuanlin.,Zhang, Jing.,...&Zhu, Yong.(2022).The Effect of Long-Term Moderate Static Magnetic Field Exposure on Adult Female Mice.BIOLOGY-BASEL,11.
MLA	Yang, Xingxing,et al."The Effect of Long-Term Moderate Static Magnetic Field Exposure on Adult Female Mice".BIOLOGY-BASEL 11(2022).