The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma

doi:10.3389/fgene.2022.983672

	The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma
	Wang, Xiaojing 2,3; Zhao, Yue 1,4; Strohmer, Dorothee Franziska 4; Yang, Wenjin 2; Xia, Zhijia 4; Yu, Cong 2
刊名	FRONTIERS IN GENETICS
	2022-08-30
卷号	13
关键词	fatty acid metabolism MicroRNAs head and neck squamous cell carcinoma prognostic risk score
DOI	10.3389/fgene.2022.983672
通讯作者	Xia, Zhijia(Zhijia.Xia@med.uni-muenchen.de) ; Yu, Cong(yucong18270916759@163.com)
英文摘要	Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer in humans globally. In addition to smoking and drinking, genetic and epigenetic changes also play a big role in how HNSCC starts and grows. MicroRNAs are short, non-coding RNAs that control cell differentiation and apoptosis by interfering with gene expression. In addition, microRNAs in HNSCC have been shown to affect the clinical behaviors of HNSCC in amazing ways. Moreover, metabolic reprogramming is a key part of cancer and is needed for cancer to turn into a tumor and grow. But it is still not clear what effect microRNAs related to fatty acid metabolism have on the prognosis of HNSCC patients. We downloaded the data of HNSCC patients from the TCGA database and obtained the genes associated with fatty acid metabolism according to the GSEA database. Then, the microRNAs associated with fatty acid metabolism genes were matched. Finally, fatty acid metabolism gene associated microRNAs for calculating risk scores and then building multifactorial Cox regression models in patients with HNSCC. Heatmap analysis showed that microRNAs involved in fatty acid metabolism were significantly different in HNSCC patients than in healthy controls. A total of 27 microRNAs associated with fatty acid metabolism were screened by univariate Cox analysis (p < 0.05). Using lasso regression, 18 microRNAs substantially linked with the prognosis of HNSCC patients were identified and included in risk scores. The ROC curves demonstrate that risk scores derived from microRNAs involved in fatty acid metabolism can accurately predict the prognosis of HNSCC patients at 1, 3, and 5 years. Moreover, we discovered that 11 microRNAs included in the risk score properly distinguished the prognosis of HNSCC patients. This paper indicated that microRNAs involved with fatty acid metabolism are strongly linked to the prognosis of HNSCC patients. It also indicated that reprogramming of fatty acid metabolism in tumor tissues may play an important role in HNSCC cancer.
资助项目	Pudong Health Commission of Shanghai ; [PW2020A-14]
WOS关键词	TUMOR MICROENVIRONMENT ; INHIBITION
WOS研究方向	Genetics & Heredity
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000883142400001
资助机构	Pudong Health Commission of Shanghai
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/130110]
专题	中国科学院合肥物质科学研究院
通讯作者	Xia, Zhijia; Yu, Cong
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Breast Surg, Canc Hosp, Hangzhou, Peoples R China 2.Shanghai Pudong New Area Peoples Hosp, Dept Neurosurg, Shanghai, Peoples R China 3.Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei, Peoples R China 4.Ludwig Maximilians Univ Munchen, Dept Gen Visceral & Transplant Surg, Munich, Germany
推荐引用方式 GB/T 7714	Wang, Xiaojing,Zhao, Yue,Strohmer, Dorothee Franziska,et al. The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma[J]. FRONTIERS IN GENETICS,2022,13.
APA	Wang, Xiaojing,Zhao, Yue,Strohmer, Dorothee Franziska,Yang, Wenjin,Xia, Zhijia,&Yu, Cong.(2022).The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma.FRONTIERS IN GENETICS,13.
MLA	Wang, Xiaojing,et al."The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma".FRONTIERS IN GENETICS 13(2022).