A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus

doi:10.3389/fmicb.2022.1029366

	A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus
	Yuan, Bingqian 2,3,4,5; Lu, Xiaoyu 2,3,4,5; Yang, Min 3,4,6; He, Qiyi 7; Cha, Zhuocen 8,9; Fang, Yaqun 3; Yang, Yan 4,10; Xu, Lei 10; Yan, Jingting 10; Lai, Ren 3,4
刊名	FRONTIERS IN MICROBIOLOGY
	2022-10-10
卷号	13
关键词	Staphylococcus aureus cathelicidin antimicrobial peptides GW18 drug-resistant
DOI	10.3389/fmicb.2022.1029366
通讯作者	Wang, Aili(allie612@gmlab.ac.cn) ; Yu, Xiaodong(yxd@cqnu.edu.cn) ; Duan, Zilei(duanzilei@mail.kiz.ac.cn)
英文摘要	Staphylococcus aureus (S. aureus) is a Gram-positive pathogenic bacterium, which persistently colonizes the anterior nares of approximately 20-30% of the healthy adult population, and up to 60% is intermittently colonized. With the misuse and overuse of antibiotics, large-scale drug-resistant bacteria, including methicillin-resistant S. aureus (MRSA), have been appeared. MRSA is among the most prevalent pathogens causing community-associated infections. Once out of control, the number of deaths caused by antimicrobial resistance may exceed 10 million annually by 2050. Antimicrobial peptides (AMPs) are regarded as the best solution, for they are not easy to develop drug resistance. Based on our previous research, here we designed a new antimicrobial peptide named GW18, which showed excellent antimicrobial activity against S. aureus, even MRSA, with the hemolysis less than 5%, no cytotoxicity, and no acute toxicity. Notably, administration of GW18 significantly decreased S. aureus infection in mouse model. These findings identify GW18 as the ideal candidate against S. aureus infection.
资助项目	National Natural Science Foundation of China[31930015] ; National Natural Science Foundation of China[81770464] ; National Natural Science Foundation of China[U2002219] ; National Natural Science Foundation of China[32002311] ; Chinese Academy of Sciences[SAJC202103] ; Chinese Academy of Sciences[XDB31000000] ; Chinese Academy of Sciences[KFJ-BRP-008] ; Yunnan Provincial Science and Technology Department[202002AA100007] ; Yunnan Provincial Science and Technology Department[2019FB127] ; Yunnan Provincial Science and Technology Department[202001AT070128] ; Bureau of Industry and Information Technology of Kunming[2120784001315] ; Bureau of Industry and Information Technology of Kunming[2120784001310] ; Kunming Science and Technology Bureau[2023SCP001] ; Chongqing Municipal Education Commission[HZ2021020]
WOS关键词	PROTEASE STABILITY ; CATHELICIDIN ; LL-37 ; COMPLEX ; SEPSIS ; DNA
WOS研究方向	Microbiology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000876195100001
资助机构	National Natural Science Foundation of China ; Chinese Academy of Sciences ; Yunnan Provincial Science and Technology Department ; Bureau of Industry and Information Technology of Kunming ; Kunming Science and Technology Bureau ; Chongqing Municipal Education Commission
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/130051]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Aili; Yu, Xiaodong; Duan, Zilei
作者单位	1.Southern Marine Sci & Engn Guangdong Lab, Ctr Evolut & Conservat Biol, Guangzhou, Peoples R China 2.Tianjin Univ, Sch Life Sci, Tianjin, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool,Sino African Joint Res Ctr, Natl Resource Ctr Nonhuman Primates,Key Lab Bioact, Kunming Primate Res Ctr,Key Lab Anim Models & Huma, Kunming, Peoples R China 4.Kunming Inst Zool, Engn Lab Peptides, Kunming, Peoples R China 5.Univ Chinese Acad Sci, Chinese Acad Sci, Canc Hosp, Inst Basic Med & Canc IBMC, Hangzhou, Zhejiang, Peoples R China 6.Univ Chinese Acad Sci, Kunming Coll Life Sci, Beijing, Peoples R China 7.Chongqing Normal Univ, Coll Life Sci, Chongqing, Peoples R China 8.Kunming Med Univ, Affiliated Hosp 3, Dept Breast Surg, Kunming, Yunnan, Peoples R China 9.Yunnan Canc Hosp, Kunming, Yunnan, Peoples R China 10.Yunnan Prov Acad Sci & Technol, Kunming, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Bingqian,Lu, Xiaoyu,Yang, Min,et al. A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus[J]. FRONTIERS IN MICROBIOLOGY,2022,13.
APA	Yuan, Bingqian.,Lu, Xiaoyu.,Yang, Min.,He, Qiyi.,Cha, Zhuocen.,...&Duan, Zilei.(2022).A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus.FRONTIERS IN MICROBIOLOGY,13.
MLA	Yuan, Bingqian,et al."A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus".FRONTIERS IN MICROBIOLOGY 13(2022).