Factors associated with non-lifting of colorectal mucosal lesions

doi:10.1080/00365521.2022.2133971

	Factors associated with non-lifting of colorectal mucosal lesions
	Yu, Jiang-Ping; Yang, Shao-Peng; Ruan, Rong-Wei; Chen, Sheng-Sen; Li, Yan-Dong; Lou, Hai-Bin; Wang, Shi
刊名	SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
	2022-10-17
关键词	Non-lifting lesions musculo-fibrous of muscularis propria anomaly submucosal fibrosis endoscopic submucosal dissection
ISSN号	0036-5521
DOI	10.1080/00365521.2022.2133971
通讯作者	Wang, Shi(wangshi@zjcc.org.cn)
英文摘要	Background Endoscopic submucosal dissection (ESD) is an effective treatment for colorectal tumors. However, lesions that cannot be lifted after submucosal injection are not indication for ESD. This is because the procedure is difficult, and the lesions are often considered as tumor invasion or submucosal fibrosis. The aims of this study are to evaluate the efficacy and safety of ESD for non-lifting lesions and to analyze the causes of non-lifting phenomenon. Methods This retrospective study included 29 patients with non-lifting colon lesions resected by ESD from February 2018 to September 2021. Cases were observed for demographics, endoscopic findings, treatment outcomes, adverse events and endoscopic follow-up. We studied the pathological features of lesions to explore the reasons for non-lifting. Results Among 29 cases of non-lifting lesions, 20 lesions (69.0%) were 30 mm in diameter or larger. Most of lesions (96.6%) were non-lifting in center, and only one lesions (3.4%) had non-lifting of one side. The en bloc and curative resection rates of ESD were 100 and 86.2%, respectively. There was one (3.4%) delayed bleeding, no perforations and other complications. No tumor recurrence occurred during the follow-up period. For pathological features, 16 (55.2%) non-lifting lesions had submucosal fibrosis and only 4 cases (13.8%) had deep submucosal invasion. There were 9 cases (31.0%) of non-lifting lesions due to musculo-fibrous of muscularis propria anomaly (MMPA). Conclusion MMPA is another reason for non-lifting signs besides invasive carcinomas and submucosal fibrosis. ESD should be considered in patients with large non-lifting adenoma instead of surgery.
WOS关键词	RESECTION ; SIGN ; EMR ; MANAGEMENT ; DISSECTION ; NEOPLASIA ; AVULSION ; INVASION ; STRATEGY ; BIOPSY
WOS研究方向	Gastroenterology & Hepatology
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000869526000001
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/129416]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Shi
作者单位	Univ Chinese Acad Sci, Chinese Acad Sci, Zhejiang Canc Hosp, Dept Endoscopy,Canc Hosp,Inst Basic Med & Canc IB, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Yu, Jiang-Ping,Yang, Shao-Peng,Ruan, Rong-Wei,et al. Factors associated with non-lifting of colorectal mucosal lesions[J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY,2022.
APA	Yu, Jiang-Ping.,Yang, Shao-Peng.,Ruan, Rong-Wei.,Chen, Sheng-Sen.,Li, Yan-Dong.,...&Wang, Shi.(2022).Factors associated with non-lifting of colorectal mucosal lesions.SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY.
MLA	Yu, Jiang-Ping,et al."Factors associated with non-lifting of colorectal mucosal lesions".SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2022).