The pathogenesis of organ fibrosis: Focus on necroptosis

doi:10.1111/bph.15952

	The pathogenesis of organ fibrosis: Focus on necroptosis
	Hao, Min 1; Han, Xin 1; Yao, Zhouhui 1; Zhang, Han 2; Zhao, Mengting 1; Peng, Mengyun 1; Wang, Kuilong 1; Shan, Qiyuan 1; Sang, Xianan 1; Wu, Xin 1
刊名	BRITISH JOURNAL OF PHARMACOLOGY
	2022-10-05
关键词	liver fibrosis lung fibrosis MLKL necroptosis RIPK1 3 tissue fibrosis
ISSN号	0007-1188
DOI	10.1111/bph.15952
通讯作者	Cao, Gang(caogang33@163.com)
英文摘要	Fibrosis is a common process of tissue repair response to multiple injuries in all chronic progressive diseases, which features with excessive deposition of extracellular matrix. Fibrosis can occur in all organs and tends to be nonreversible with the progress of the disease. Different cells types in different organs are involved in the occurrence and development of fibrosis, that is, hepatic stellate cells, pancreatic stellate cells, fibroblasts and myofibroblasts. Various types of programmed cell death, including apoptosis, autophagy, ferroptosis and necroptosis, are closely related to organ fibrosis. Among these programmed cell death types, necroptosis, an emerging regulated cell death type, is regarded as a huge potential target to ameliorate organ fibrosis. In this review, we summarize the role of necroptosis signalling in organ fibrosis and collate the small molecule compounds targeting necroptosis. In addition, we discuss the potential challenges, opportunities and open questions in using necroptosis signalling as a potential target for antifibrotic therapies.
资助项目	National Natural Science Foundation of China[81922073] ; National Natural Science Foundation of China[81973481] ; National Natural Science Foundation of China[82003948] ; Zhejiang Provincial Natural Science Foundation of China[LQ21H280002] ; Zhejiang Provincial Natural Science Foundation of China[LZ22H280001] ; Basic Public Welfare Research Project in Zhejiang province[LGF18H280003] ; Zhejiang Traditional Chinese Medicine Science and Technology Plan[2021ZB084] ; Zhejiang Traditional Chinese Medicine Science and Technology Plan[2021ZZ009] ; Zhejiang Chinese Medicine University School-level Scientific Research Fund for Talents[2020ZR14]
WOS关键词	PROTEIN-KINASE 1 ; CELL-DEATH ; CONCISE GUIDE ; MEDIATES NECROPTOSIS ; OXIDATIVE STRESS ; RIP3 ; MECHANISMS ; NECROSIS ; COMPLEX ; MLKL
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	WILEY
WOS记录号	WOS:000863933200001
资助机构	National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; Basic Public Welfare Research Project in Zhejiang province ; Zhejiang Traditional Chinese Medicine Science and Technology Plan ; Zhejiang Chinese Medicine University School-level Scientific Research Fund for Talents
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/129079]
专题	中国科学院合肥物质科学研究院
通讯作者	Cao, Gang
作者单位	1.Zhejiang Chinese Med Univ, Sch Pharm, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China 2.Zhejiang Chinese Med Univ, Clin Med Coll 3, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Hao, Min,Han, Xin,Yao, Zhouhui,et al. The pathogenesis of organ fibrosis: Focus on necroptosis[J]. BRITISH JOURNAL OF PHARMACOLOGY,2022.
APA	Hao, Min.,Han, Xin.,Yao, Zhouhui.,Zhang, Han.,Zhao, Mengting.,...&Cao, Gang.(2022).The pathogenesis of organ fibrosis: Focus on necroptosis.BRITISH JOURNAL OF PHARMACOLOGY.
MLA	Hao, Min,et al."The pathogenesis of organ fibrosis: Focus on necroptosis".BRITISH JOURNAL OF PHARMACOLOGY (2022).