Low Temperature Plasma Suppresses Lung Cancer Cells Growth via VEGF/VEGFR2/RAS/ERK Axis

doi:10.3390/molecules27185934

	Low Temperature Plasma Suppresses Lung Cancer Cells Growth via VEGF/VEGFR2/RAS/ERK Axis
	Zhou, Yuanyuan 1; Zhang, Yan 1; Bao, Jie 1,2; Chen, Jinwu 1,3; Song, Wencheng 1,2,4
刊名	MOLECULES
	2022-09-01
卷号	27
关键词	low temperature plasma lung cancer cell ROS RNS cell death
DOI	10.3390/molecules27185934
通讯作者	Chen, Jinwu(yunliuqiye@163.com) ; Song, Wencheng(wencsong@cmpt.ac.cn)
英文摘要	Low temperature plasma (LTP) is a promising cancer therapy in clinical practice. In this study, dielectric barrier discharge plasma with helium gas was used to generate LTP. Significant increases in extracellular and intracellular reactive species were found in lung cancer cells (CALU-1 and SPC-A1) after LTP treatments. Cells viability and apoptosis assays demonstrated that LTP inhibited cells viability and induced cells death, respectively. Moreover, Western blotting revealed that the growth of CALU-1 cells was suppressed by LTP via the VEGF/VEGFR2/RAS/ERK axis for the first time. The results showed that LTP-induced ROS and RNS could inhibit the growth of lung cancer cells via VEGF/VEGFR2/RAS/ERK axis. These findings advance our understanding of the inhibitory mechanism of LTP on lung cancer and will facilitate its clinical application.
资助项目	National Natural Science Foundation of China[21876179] ; National Natural Science Foundation of China[22006001] ; China Postdoctoral Science Foundation[2020T130117ZX] ; China Postdoctoral Science Foundation[2020M671914] ; China Postdoctoral Science Foundation[2020B470]
WOS关键词	PATHWAY ; INHIBITOR ; SURVIVAL ; VEGF ; RAF
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000856760900001
资助机构	National Natural Science Foundation of China ; China Postdoctoral Science Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/128968]
专题	中国科学院合肥物质科学研究院
通讯作者	Chen, Jinwu; Song, Wencheng
作者单位	1.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China 2.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China 3.Hefei Normal Univ, Sch Life Sci, Hefei 230061, Peoples R China 4.Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst & Sch Radiol & Interdisc, Suzhou 215123, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Yuanyuan,Zhang, Yan,Bao, Jie,et al. Low Temperature Plasma Suppresses Lung Cancer Cells Growth via VEGF/VEGFR2/RAS/ERK Axis[J]. MOLECULES,2022,27.
APA	Zhou, Yuanyuan,Zhang, Yan,Bao, Jie,Chen, Jinwu,&Song, Wencheng.(2022).Low Temperature Plasma Suppresses Lung Cancer Cells Growth via VEGF/VEGFR2/RAS/ERK Axis.MOLECULES,27.
MLA	Zhou, Yuanyuan,et al."Low Temperature Plasma Suppresses Lung Cancer Cells Growth via VEGF/VEGFR2/RAS/ERK Axis".MOLECULES 27(2022).