Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis

doi:10.1002/smll.202204694

	Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis
	Zhao, ChuanRong 7,8,9; Li, Jingyi 6; Jiang, ZhiTong 5,7,8,9; Zhu, JuanJuan 7,8,9; Zhao, JiaNan 7,8,9; Yang, QianRu 7,8,9; Yao, Weijuan 9; Pang, Wei 9; Li N(李宁)2,3,4; Yu, Miaorong 1,6
刊名	SMALL
	2022-11-20
页码	15
关键词	atherosclerosis decitabine endothelial inflammation hemodynamics nanoparticles
ISSN号	1613-6810
DOI	10.1002/smll.202204694
通讯作者	Yu, Miaorong(mryu@simm.ac.cn) ; Gan, Yong(ygan@simm.ac.cn) ; Zhou, Jing(jzhou@bjmu.edu.cn)
英文摘要	Disturbed blood flow induces endothelial pro-inflammatory responses that promote atherogenesis. Nanoparticle-based therapeutics aimed at treating endothelial inflammation in vasculature where disturbed flow occurs may provide a promising avenue to prevent atherosclerosis. By using a vertical-step flow apparatus and a microfluidic chip of vascular stenosis, herein, it is found that the disk-shaped versus the spherical nanoparticles exhibit preferential margination (localization and adhesion) to the regions with the pro-atherogenic disturbed flow. By employing a mouse model of carotid partial ligation, superior targeting and higher accumulation of the disk-shaped particles are also demonstrated within disturbed flow areas than that of the spherical particles. In hyperlipidemia mice, administration of disk-shaped particles loaded with hypomethylating agent decitabine (DAC) displays greater anti-inflammatory and anti-atherosclerotic effects compared with that of the spherical counterparts and exhibits reduced toxicity than "naked" DAC. The findings suggest that shaping nanoparticles to disk is an effective strategy for promoting their delivery to atheroprone endothelia.
分类号	一类
资助项目	National Natural Science Foundation of China ; Ministry of Science and Technology ; [32201071] ; [81974052] ; [82270419] ; [81921001] ; [82073773] ; [82025032] ; [2022YFC2704300]
WOS关键词	IN-VIVO ; SHAPE ; NANOPARTICLES ; ADHESION ; CELLS ; ENDOTHELIUM ; DECITABINE ; PARTICLES ; MECHANISM ; DYNAMICS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000888373300001
资助机构	National Natural Science Foundation of China ; Ministry of Science and Technology
其他责任者	Yu, Miaorong ; Gan, Yong ; Zhou, Jing
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/90813]
专题	力学研究所_国家微重力实验室
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China; 4.Chinese Acad Sci, Key Lab Micrograv, Natl Micrograv Lab, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China; 5.Peking Univ, Shenzhen Hosp, Dept Cardiovasc Surg, Shenzhen 518036, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 7.Peking Univ, Natl Hlth Commiss Key Lab Cardiovasc Mol Biol & Re, Beijing Key Lab Cardiovasc Receptors Res, Beijing 100191, Peoples R China; 8.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China; 9.Peking Univ, Hemorheol Ctr, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China;
推荐引用方式 GB/T 7714	Zhao, ChuanRong,Li, Jingyi,Jiang, ZhiTong,et al. Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis[J]. SMALL,2022:15.
APA	Zhao, ChuanRong.,Li, Jingyi.,Jiang, ZhiTong.,Zhu, JuanJuan.,Zhao, JiaNan.,...&Zhou, Jing.(2022).Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis.SMALL,15.
MLA	Zhao, ChuanRong,et al."Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis".SMALL (2022):15.