The Dual-Targeted Peptide Conjugated Probe for Depicting Residual Nasopharyngeal Carcinoma and Guiding Surgery

doi:10.3390/bios12090729

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	The Dual-Targeted Peptide Conjugated Probe for Depicting Residual Nasopharyngeal Carcinoma and Guiding Surgery
	Huang, Wenhui 1,2,3; He, Zicong 2; Cai, Xuekang 4; Zhang, Jingming 4; Li, Wei 2,3; Wang, Kun 3; Zhang, Shuixing 2
刊名	BIOSENSORS-BASEL
	2022-09-01
卷号	12 期号:9 页码:14
关键词	nasopharyngeal carcinoma HER2 SR-BI optoacoustic imaging fluorescence molecular imaging imaging-guided surgery
DOI	10.3390/bios12090729
通讯作者	Wang, Kun(kun.wang@ia.ac.cn) ; Zhang, Shuixing(zsx7515@jnu.edu.cn)
英文摘要	Detecting residual nasopharyngeal carcinoma (rNPC) can be difficult because of the coexistence of occult tumours and post-chemoradiation changes, which poses a challenge for both radiologists and surgeons using current imaging methods. Currently, molecular imaging that precisely targets and visualises particular biomarkers in tumours may exceed the specificity and sensitivity of traditional imaging techniques, providing the potential to distinguish tumours from non-neoplastic lesions. Here, we synthesised a HER2/SR-BI-targeted tracer to efficiently position NPC and guide surgery in living mice. This bispecific tracer contained the following two parts: IRDye 800 CW, as an imaging reagent for both optical and optoacoustic imaging, and a fusion peptide (FY-35), as the targeting reagent. Both in vitro and in vivo tests demonstrated that the tracer had higher accumulation and longer retention (up to 48 h) in tumours than a single-targeted probe, and realised sensitive detection of tumours with a minimum size of 3.9 mm. By visualising the vascular network via a customised handheld optoacoustic scan, our intraoperative fluorescence molecular imaging system provides accurate guidance for intraoperative tumour resection. Integrating the advantages of both optical and optoacoustic scanning in an intraoperative image-guided system, this method holds promise for depicting rNPC and guiding salvage surgery.
资助项目	National Natural Science Foundation of China[82027803] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81871323] ; Chinese Academy of Sciences[YJKYYQ20180048] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Excellent Member Project of Youth Innovation Promotion Association CAS[2016124] ; Project of High-Level Talents Team Introduction in Zhuhai City
WOS关键词	OPEN-LABEL ; GUIDED SURGERY ; CANCER ; RADIOTHERAPY ; MULTICENTER ; GROWTH ; HEAD ; HER2
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation
语种	英语
出版者	MDPI
WOS记录号	WOS:000856318600001
资助机构	National Natural Science Foundation of China ; Chinese Academy of Sciences ; Excellent Member Project of Youth Innovation Promotion Association CAS ; Project of High-Level Talents Team Introduction in Zhuhai City
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/50125]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Wang, Kun; Zhang, Shuixing
作者单位	1.Northeastern Univ, Coll Med & Biol Informat Engn, Shenyang 110167, Peoples R China 2.Jinan Univ, Affiliated Hosp 1, Med Imaging Ctr, Guangzhou 510630, Peoples R China 3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 4.Peking Univ First Hosp, Dept Nucl Med, Beijing 100034, Peoples R China
推荐引用方式 GB/T 7714	Huang, Wenhui,He, Zicong,Cai, Xuekang,et al. The Dual-Targeted Peptide Conjugated Probe for Depicting Residual Nasopharyngeal Carcinoma and Guiding Surgery[J]. BIOSENSORS-BASEL,2022,12(9):14.
APA	Huang, Wenhui.,He, Zicong.,Cai, Xuekang.,Zhang, Jingming.,Li, Wei.,...&Zhang, Shuixing.(2022).The Dual-Targeted Peptide Conjugated Probe for Depicting Residual Nasopharyngeal Carcinoma and Guiding Surgery.BIOSENSORS-BASEL,12(9),14.
MLA	Huang, Wenhui,et al."The Dual-Targeted Peptide Conjugated Probe for Depicting Residual Nasopharyngeal Carcinoma and Guiding Surgery".BIOSENSORS-BASEL 12.9(2022):14.