Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity

	Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity
	Wang, F; Qi, XW; Geng, JH; Liu, XY; Li, D; Zhang, H; Zhang, P; He, XL; Li, BW; Li, ZJ
刊名	JOURNAL OF MOLECULAR LIQUIDS
	2022
卷号	347
英文摘要	Monodisperse hollow mesoporous Fe3O4 nanospheres have been successfully synthesized via a template-free one-pot solvothermal method under the existence of iron chloride hexahydrate, polyvinylpyrrolidone and urea. A proposed gas-bubble-assisted Ostwald ripening mechanism was allowed to explain the possible fabrication of hollow nanostructures. The formed Fe3O4 nanospheres possessed a narrow particle size distribution with a average hydrodynamic diameter of 392 nm, superparamagnetic characteristics with high saturation magnetization of 74.9 emu/g, as well as the typical mesoporous structures with specific surface area of 27.3 m(2)/g. Furthermore, it was found that the bare hollow mesoporous Fe3O4 nanospheres showed an insignificant cytotoxicity, but exhibited obvious cytotoxic effects towards HeLa cells after being loaded with the anti-cancer drug of DOX, which could be recommended as a promising and effective drug delivery system with high drug loading capacity and pH-responsive feature. The determined maximum drug loading capacity of DOX on this kind of hollow mesoporous Fe3O4 nanospheres was as high as 0.36 +/- 0.04 g/g, which can store and deliver effectively the anticancer drugs to induce death of cancer cells. (C) 2021 Elsevier B.V. All rights reserved.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/61301]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Wang, F,Qi, XW,Geng, JH,et al. Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity[J]. JOURNAL OF MOLECULAR LIQUIDS,2022,347.
APA	Wang, F.,Qi, XW.,Geng, JH.,Liu, XY.,Li, D.,...&Wang, GS.(2022).Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity.JOURNAL OF MOLECULAR LIQUIDS,347.
MLA	Wang, F,et al."Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity".JOURNAL OF MOLECULAR LIQUIDS 347(2022).