COVID-19-inspired "artificial virus" to combat drug-resistant bacteria by membrane-intercalation- photothermal-photodynamic multistage effects

	COVID-19-inspired "artificial virus" to combat drug-resistant bacteria by membrane-intercalation- photothermal-photodynamic multistage effects
	Ni, YS; Wang, JY; Wang, MY; Liu, LZ; Nie, HQ; Wang, QL; Sun, J; Yue, TL; Zhu, MQ; Wang, JL
刊名	CHEMICAL ENGINEERING JOURNAL
	2022
卷号	446
英文摘要	COVID-19 threatens human life because of the super destructiveness produced from its coronal morphology and strong transmembrane infection based on spike glycoprotein. Inspired by the coronal morphology of COVID-19 and its means of infecting, we designed an "artificial virus" with coronal morphology based on the concept of "defeating superbacteria with superviruses" by self-assembling a transacting activator of transduction peptide with triple-shell porous graphitic carbon nitride (g-C3N4) embedded with cobalt nanoparticles to forcefully infect methicillin-resistant Staphylococcus aureus (MRSA). The results confirmed that this "artificial virus" had unique properties of crossing the bacterial cell membrane barrier, heating the internal bacterial microenvironment and triggering ROS outbreak, based on its coronal morphology, membrane penetration, temperature-rising and heat insulation, oxidase-like activity and excellent visible-light harvesting properties. It had a high sterilization efficiency of 99.99% at 20 min, which was 18.6 times that of g-C3N4, and the efficiency remained at 99.99% after 3 rounds of recycling and reuse. Additionally, it can rapidly inactivate bacteria in river water and accelerate wound healing.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/61075]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Ni, YS,Wang, JY,Wang, MY,et al. COVID-19-inspired "artificial virus" to combat drug-resistant bacteria by membrane-intercalation- photothermal-photodynamic multistage effects[J]. CHEMICAL ENGINEERING JOURNAL,2022,446.
APA	Ni, YS.,Wang, JY.,Wang, MY.,Liu, LZ.,Nie, HQ.,...&Wang, JL.(2022).COVID-19-inspired "artificial virus" to combat drug-resistant bacteria by membrane-intercalation- photothermal-photodynamic multistage effects.CHEMICAL ENGINEERING JOURNAL,446.
MLA	Ni, YS,et al."COVID-19-inspired "artificial virus" to combat drug-resistant bacteria by membrane-intercalation- photothermal-photodynamic multistage effects".CHEMICAL ENGINEERING JOURNAL 446(2022).